Microperfusion of 3-MPA into the brain augments GABA.
Microperfusion of 3-MPA into the brain augments GABA.
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DOI：
10.1016/j.yebeh.2013.08.026
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Lunte CE
中科院分区：
文献类型：
--
作者：
Mayer AP;Osorio I;Lunte CE
研究了在体纹状体和海马微灌注GABA合成抑制剂（3-MPA）对氨基酸浓度和电神经元活动的影响。纹状体中GABA的异常升高（麻醉大鼠5倍，清醒大鼠50倍）和海马在稳态浓度的3-MPA沿着预期的谷氨酸增加下，（麻醉和清醒大鼠的纹状体分别增加15倍和250倍;在麻醉和清醒大鼠的海马体中分别增加7倍和25倍）。没有明显的癫痫样或癫痫发作活动。的矛盾增加GABA的approachations提供，并强调被放置在依赖的模型中，其影响进行了研究，以及在当时的水平上的激活的探测网络的去抑制。
In vivo effects of microperfusion of a GABA synthesis inhibitor (3-MPA) into the striatum and hippocampus on amino acid concentrations and electrical neuronal activity were investigated. Paradoxical elevations in GABA in the striatum (5-fold in anesthetized and 50-fold in awake rats) and hippocampus (2-fold in anesthetized and 15-fold in awake rats) were documented under steady-state concentrations of 3-MPA along with expected increases in glutamate (a 15-fold increase and a 250-fold increase in the striatum of anesthetized and awake rats, respectively; a 7-fold increase and a 25-fold increase in the hippocampus of anesthetized and awake rats, respectively). There was no clear epileptiform or seizure activity. Explanations for the paradoxical increase in GABA are offered, and emphasis is placed on the dependency of disinhibition on the model in which its effects are studied as well as on the prevailing level of activation of the probed network.
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DOI：
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