Development of the corticothalamic projections.

Development of the corticothalamic projections.
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皮质丘脑预测的开发。

DOI:
10.3389/fnins.2012.00053
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发表时间:
2012
影响因子:
4.3
通讯作者:
Molnár Z
Molnár Z
中科院分区:
医学2区
文献类型:
--
作者:
Grant E;Hoerder-Suabedissen A;Molnár Z

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在这篇综述中,我们讨论了最近的进展,在了解皮质丘脑轴突的指导,图案化的早期端脑,序列和编排的发展亚板,层5和6的预测。这些皮质亚群显示不同的轴突生长动力学和支配不同的丘脑核团的皮质层身份和子类特异性所确定的时间模式。分子线索、结构线索和活性依赖机制的指导有助于这种发展。有一个实质性的重新排列的丘脑外的皮质连接的边缘和网状丘脑核内,一个区域,在发展过程中的皮质基板的一些特征。早期的瞬态电路还没有很好的理解,也没有在何种程度上,这种发展模式可能是由外周感觉活动。我们假设,在胚胎和出生后早期的发展过程中的瞬态电路是至关重要的匹配的皮质和丘脑的代表性和形成的皮质电路在成熟的大脑。
In this review we discuss recent advances in the understanding of corticothalamic axon guidance; patterning of the early telencephalon, the sequence and choreography of the development of projections from subplate, layers 5 and 6. These cortical subpopulations display different axonal outgrowth kinetics and innervate distinct thalamic nuclei in a temporal pattern determined by cortical layer identity and subclass specificity. Guidance by molecular cues, structural cues, and activity-dependent mechanisms contribute to this development. There is a substantial rearrangement of the corticofugal connectivity outside the thalamus at the border of and within the reticular thalamic nucleus, a region that shares some of the characteristics of the cortical subplate during development. The early transient circuits are not well understood, nor the extent to which this developmental pattern may be driven by peripheral sensory activity. We hypothesize that transient circuits during embryonic and early postnatal development are critical in the matching of the cortical and thalamic representations and forming the cortical circuits in the mature brain.
DOI: 10.1242/dev.02379
发表时间: 2006-06-01
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影响因子: 4.6
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