Development, validation and testing of an epidemiological case definition of interstitial cystitis/painful bladder syndrome.
Development, validation and testing of an epidemiological case definition of interstitial cystitis/painful bladder syndrome.
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DOI：
10.1016/j.juro.2009.12.103
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Clemens JQ
中科院分区：
文献类型：
--
作者：
Berry SH;Bogart LM;Pham C;Liu K;Nyberg L;Stoto M;Suttorp M;Clemens JQ
对于患者筛选或流行病学研究，间质性膀胱炎/膀胱疼痛综合征没有标准病例定义。作为兰德间质性膀胱炎流行病学研究的一部分，我们制定了间质性膀胱炎/膀胱疼痛综合征的病例定义，具有已知的敏感性和特异性。我们将此定义与间质性膀胱炎/膀胱疼痛综合征流行病学研究中使用的其他定义进行了比较。我们回顾了文献，并进行了一个结构化的，专家小组的过程，以达到间质性膀胱炎/膀胱疼痛综合征的病例定义。我们使用该病例定义和文献中使用的其他定义制定了一份问卷，以评估间质性膀胱炎/膀胱疼痛综合征症状。我们对599名患有间质性膀胱炎/膀胱疼痛综合征、膀胱过度活动症、子宫内膜异位症或外阴痛的妇女进行了问卷调查。使用医生指定的诊断作为参考标准，计算每个定义的灵敏度和特异性。没有一个流行病学定义具有高敏感性和高特异性。因此，制定了两个定义。一种敏感性高（81%），特异性低（54%），另一种敏感性低（48%），特异性低（83%）。这些值与间质性膀胱炎/膀胱疼痛综合征患病率研究中使用的其他流行病学定义的值相当或上级。间质性膀胱炎/膀胱疼痛综合征的单一病例定义无法提供识别该病症的高灵敏度和高特异性。对于间质性膀胱炎/膀胱疼痛综合征的患病率研究，最好的方法可能是使用2个定义，得出患病率范围。通过结构化共识和验证制定的兰德间质性膀胱炎流行病学间质性膀胱炎/膀胱疼痛综合征病例定义可用于此目的。
No standard case definition exists for interstitial cystitis/painful bladder syndrome for patient screening or epidemiological studies. As part of the RAND Interstitial Cystitis Epidemiology study, we developed a case definition for interstitial cystitis/painful bladder syndrome with known sensitivity and specificity. We compared this definition with others used in interstitial cystitis/painful bladder syndrome epidemiological studies. We reviewed the literature and performed a structured, expert panel process to arrive at an interstitial cystitis/painful bladder syndrome case definition. We developed a questionnaire to assess interstitial cystitis/painful bladder syndrome symptoms using this case definition and others used in the literature. We administered the questionnaire to 599 women with interstitial cystitis/painful bladder syndrome, overactive bladder, endometriosis or vulvodynia. The sensitivity and specificity of each definition was calculated using physician assigned diagnoses as the reference standard. No single epidemiological definition had high sensitivity and high specificity. Thus, 2 definitions were developed. One had high sensitivity (81%) and low specificity (54%), and the other had the converse (48% sensitivity and 83% specificity). These values were comparable or superior to those of other epidemiological definitions used in interstitial cystitis/painful bladder syndrome prevalence studies. No single case definition of interstitial cystitis/painful bladder syndrome provides high sensitivity and high specificity to identify the condition. For prevalence studies of interstitial cystitis/painful bladder syndrome the best approach may be to use 2 definitions that would yield a prevalence range. The RAND Interstitial Cystitis Epidemiology interstitial cystitis/painful bladder syndrome case definitions, developed through structured consensus and validation, can be used for this purpose.
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