Long-term acclimatization to high-altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain.
Long-term acclimatization to high-altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain.
复制标题
长期适应高海拔缺氧会改变成人大脑半球间的功能和结构连接。
DOI：
10.1002/brb3.512
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发表时间：
2016-09
影响因子：
3.1
通讯作者：
Zhang, Jiaxing
中科院分区：
文献类型：
--
作者：
Chen, Ji;Li, Jinqiang;Han, Qiaoqing;Lin, Jianzhong;Yang, Tianhe;Chen, Ziqian;Zhang, Jiaxing
关键词：
结构和功能网络可以重组，以适应环境压力和成人大脑的生理变化，但在长期适应高海拔（HA）缺氧中，这些过程仍不清楚。本研究的目的是表征大脑半球间的功能和结构耦合的修改成人HA移民。我们对16名移居青藏高原（2300-4400 m）2年的成年人和16名年龄匹配的海平面（SL）对照者进行了静息态功能磁共振成像（fMRI）和弥散张量成像（DTI）。最近验证的体素镜像同伦连接（VMHC）的方法被用来检查大脑半球间的静息状态功能连接。选择HA移民中显示VMHC变化的区域作为随访DTI纤维束成像分析的感兴趣区域。得到了分数各向异性光纤参数和光纤长度。进行认知和生理评估，并与所得图像指标相关联。与SL对照组相比，HA移民双侧视皮层VMHC显著增加。视觉皮层内提取的平均VMHC值与血红蛋白浓度呈正相关。此外，在HA移民中，连接同视区的连合纤维的路径长度增加，与VMHC呈正相关。这些观察结果首次证明了在长时间HA适应后，成人大脑中半球间的功能和结构连接恢复力独立于遗传和发育影响，并且双侧视觉皮层中的耦合修饰表明生理适应良好的HA移民中视觉功能障碍的重要神经代偿机制。人类对极端环境的中枢适应性研究促进了对我们大脑生存能力的理解。
Structural and functional networks can be reorganized to adjust to environmental pressures and physiologic changes in the adult brain, but such processes remain unclear in prolonged adaptation to high‐altitude (HA) hypoxia. This study aimed to characterize the interhemispheric functionally and structurally coupled modifications in the brains of adult HA immigrants. We performed resting‐state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in 16 adults who had immigrated to the Qinghai‐Tibet Plateau (2300–4400 m) for 2 years and in 16 age‐matched sea‐level (SL) controls. A recently validated approach of voxel‐mirrored homotopic connectivity (VMHC) was employed to examine the interhemispheric resting‐state functional connectivity. Areas showing changed VMHC in HA immigrants were selected as regions of interest for follow‐up DTI tractography analysis. The fiber parameters of fractional anisotropy and fiber length were obtained. Cognitive and physiological assessments were made and correlated with the resulting image metrics. Compared with SL controls, VMHC in the bilateral visual cortex was significantly increased in HA immigrants. The mean VMHC value extracted within the visual cortex was positively correlated with hemoglobin concentration. Moreover, the path length of the commissural fibers connecting homotopic visual areas was increased in HA immigrants, covarying positively with VMHC. These observations are the first to demonstrate interhemispheric functional and structural connectivity resilience in the adult brain after prolonged HA acclimatization independent of inherited and developmental effects, and the coupled modifications in the bilateral visual cortex indicate important neural compensatory mechanisms underlying visual dysfunction in physiologically well‐acclimatized HA immigrants. The study of human central adaptation to extreme environments promotes the understanding of our brain's capacity for survival.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
5.7
作者：
Beall, Erik B.;Lowe, Mark J.
通讯作者：
Lowe, Mark J.
长期适应高海拔缺氧后成人大脑区域内同步神经活动增加：一项静息态功能磁共振成像研究。
影响因子：
2.1
作者：
Chen, Ji;Fan, Cunxiu;Zhang, Jiaxing
通讯作者：
Zhang, Jiaxing
影响因子：
5.5
作者：
Huang, Benjamin Y.;Castillo, Mauricio
通讯作者：
Castillo, Mauricio