Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice.
Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice.
复制标题
中药枸杞多糖诱导 H22 荷瘤小鼠全身和局部免疫反应
DOI：
10.1155/2018/3431782
复制
发表时间：
2018
影响因子：
4.1
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Deng X;Luo S;Luo X;Hu M;Ma F;Wang Y;Lai X;Zhou L
Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum. Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice. However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional changes of T cells, is still largely unknown. In the present study, we investigated the effects of LBP on systemic and local T cell-dependent antitumor immune responses in H22 tumor-bearing mice. The results showed that LBP could inhibit the solid tumor growth in mice, but showed little effect on the body weight or spleen index. Furthermore, LBP could maintain high levels of T cells in peripheral blood (PB), tumor draining lymph node (TDLN), and tumor tissue, prevent the increase of Tregs while promote infiltration of CD8+ T cells in tumor tissue, inhibit the production of TGF-β1 and IL-10 in serum, decrease the exhaustion phenotype of T cells, and maintain cytotoxicity of lymphocytes. Taken together, our results demonstrated that LBP simultaneously induced systemic and local immune responses in H22 tumor-bearing mice by alleviating immunosuppression and maintaining antitumor immune responses in mice.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
30.5
作者：
通讯作者：
--
CD8+ T细胞和CD4+ T细胞的同时浸润是非小细胞肺癌中的一个有利的预后因素。
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
2.8
作者：
Luo, Xia;Zheng, Yanyi;Liao, Haifeng
通讯作者：
Liao, Haifeng
PD-L1 表达与软组织肉瘤的 FOXP3 调节性 T 细胞浸润和患者预后不良相关
影响因子：
3.9
作者：
Que Y;Xiao W;Guan YX;Liang Y;Yan SM;Chen HY;Li QQ;Xu BS;Zhou ZW;Zhang X
通讯作者：
Zhang X