Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides.
Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides.
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DOI：
10.1002/cbic.202000430
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发表时间：
2021-01-15
期刊：
影响因子：
--
通讯作者：
Castagnolo D
中科院分区：
文献类型：
--
作者：
Anselmi S;Aggarwal N;Moody TS;Castagnolo D
亚砜是一类在医药和有机化学中有着广泛应用的有机化合物。生物催化合成对映体富集亚砜的方法有多种，主要是利用氧化酶。最近，使用还原酶如Msr和Dms已成为一种新的替代方法，从外消旋混合物中获得对映体纯亚砜。与此同时，采用非经典溶剂如离子液体（IL）和低共熔溶剂（DES）的新型氧化方法已被开发为更绿色和更可持续的生物催化合成途径。本文综述了近年来生物催化合成对映体富集亚砜的研究进展。 更环保：对映体富集亚砜可以通过利用新的还原酶Msr和Dms或在非常规溶剂存在下使用经典氧化酶以更绿色和更可持续的方式合成。
Sulfoxides are a class of organic compounds that find wide application in medicinal and organic chemistry. Several biocatalytic approaches have been developed to synthesise enantioenriched sulfoxides, mainly by exploiting oxidative enzymes. Recently, the use of reductive enzymes such as Msr and Dms has emerged as a new, alternative method to obtain enantiopure sulfoxides from racemic mixtures. In parallel, novel oxidative approaches, employing nonclassical solvents such as ionic liquids (ILs) and deep eutectic solvents (DESs), have been developed as greener and more sustainable biocatalytic synthetic pathways. This minireview aims highlights the recent advances made in the biocatalytic synthesis of enantioenriched sulfoxides by employing such unconventional approaches. Going greener: Enantioenriched sulfoxides can be synthesized by exploiting the new reductive enzymes Msr and Dms or using classical oxidative enzymes in the presence of unconventional solvents in a greener and more sustainable way.
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