Vestibular/ocular motor symptoms in concussed adolescents are linked to retrosplenial activation.
Vestibular/ocular motor symptoms in concussed adolescents are linked to retrosplenial activation.
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DOI：
10.1093/braincomms/fcac123
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发表时间：
2022
影响因子：
4.8
通讯作者：
Versace, Amelia
中科院分区：
文献类型：
--
作者：
Manelis, Anna;Lima Santos, Joao Paulo;Suss, Stephen J.;Holland, Cynthia L.;Stiffler, Richelle S.;Bitzer, Hannah B.;Mailliard, Sarrah;Shaffer, Madelyn A.;Caviston, Kaitlin;Collins, Michael W.;Phillips, Mary L.;Kontos, Anthony P.;Versace, Amelia
脑震荡后，青少年经常会出现前庭和眼部运动症状以及工作记忆缺陷，这可能会影响他们的认知、学业和社交健康。复杂的视觉环境，包括学校活动、体育运动或与朋友社交，可能会让患有头痛、头晕、恶心和雾气的脑震荡青少年感到不知所措，从而对工作记忆在此类环境中充分发挥作用提出了更高的要求。虽然了解工作记忆与前庭/眼运动症状之间的关系至关重要，但之前没有研究探讨工作记忆任务难度的增加如何影响前庭/眼运动症状的严重程度与工作记忆任务中的大脑和行为反应之间的关系。为了解决这个问题，我们使用功能性 MRI 检查了 80 名青少年（53 名脑震荡，27 名非脑震荡），同时使用愤怒、快乐、中性和悲伤的面部干扰项执行 1-back（简单）和 2-back（困难）工作记忆任务。脑震荡青少年完成了前庭/眼部运动筛查，并在受伤后 10 天内进行了扫描。我们发现，与简单（1-back）任务相比，所有参与者在困难（2-back）任务上表现出较低的准确性和较慢的反应时间（P值 < 0.05）。在所有条件下，脑震荡青少年的反应速度均明显慢于对照组（P < 0.05）。在脑震荡青少年中，较高的前庭/眼动筛查总分与所有牵引器条件下 1 背和 2 背之间反应时间的显着差异显着相关，并且在使用中性面部牵引器的 1 背与 2 背条件下压后皮层激活差异显着更大（P 值 < 0.05）。我们的研究结果表明，处理情绪模糊的信息（例如中性面孔）还会增加脑震荡青少年的任务难度。脑震荡后前庭/眼部运动症状可能会降低工作记忆任务期间抑制情绪模糊信息的能力，从而可能影响脑震荡青少年的认知、学业和社会功能。马内利斯等人。报告称，脑震荡后前庭/眼部症状与工作记忆任务期间任务难度相关的压后皮层激活减少有关。脑震荡破坏了工作记忆回路内激活和失活之间的平衡，因此可能导致困难认知任务中的神经认知资源耗尽
Following concussion, adolescents often experience vestibular and ocular motor symptoms as well as working memory deficits that may affect their cognitive, academic and social well-being. Complex visual environments including school activities, playing sports, or socializing with friends may be overwhelming for concussed adolescents suffering from headache, dizziness, nausea and fogginess, thus imposing heightened requirements on working memory to adequately function in such environments. While understanding the relationship between working memory and vestibular/ocular motor symptoms is critically important, no previous study has examined how an increase in working memory task difficulty affects the relationship between severity of vestibular/ocular motor symptoms and brain and behavioural responses in a working memory task. To address this question, we examined 80 adolescents (53 concussed, 27 non-concussed) using functional MRI while performing a 1-back (easy) and 2-back (difficult) working memory tasks with angry, happy, neutral and sad face distractors. Concussed adolescents completed the vestibular/ocular motor screening and were scanned within 10 days of injury. We found that all participants showed lower accuracy and slower reaction time on difficult (2-back) versus easy (1-back) tasks (P-values < 0.05). Concussed adolescents were significantly slower than controls across all conditions (P < 0.05). In concussed adolescents, higher vestibular/ocular motor screening total scores were associated with significantly greater differences in reaction time between 1-back and 2-back across all distractor conditions and significantly greater differences in retrosplenial cortex activation for the 1-back versus 2-back condition with neutral face distractors (P-values < 0.05). Our findings suggest that processing of emotionally ambiguous information (e.g. neutral faces) additionally increases the task difficulty for concussed adolescents. Post-concussion vestibular/ocular motor symptoms may reduce the ability to inhibit emotionally ambiguous information during working memory tasks, potentially affecting cognitive, academic and social functioning in concussed adolescents. Manelis et al. report that post-concussion vestibular/ocular symptoms are associated with task difficulty-related decreases in retrosplenial cortex activation during a working memory task. Concussion disrupts the balance between activation and deactivation within the working memory circuitry, thus, potentially, leading to neurocognitive resource depletion in difficult cognitive tasks
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