Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography.
Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography.
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DOI：
10.1177/1550059420909658
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发表时间：
2020-09
影响因子：
2
通讯作者：
Eswaran H
中科院分区：
文献类型：
--
作者：
Avci R;Whittington JR;Blossom SJ;Escalona-Vargas D;Siegel ER;Preissl HT;Eswaran H
Developmental Origin of Health and Disease states that an adverse intrauterine environment can lead to different diseases in later life. In this study, we aimed to explore the effect of maternal pregestational diabetes on the fetal brain activity using magnetoencephalography (MEG). Forty participants were included in an observational study with nine type 1 and 19 type 2 diabetic pregnant women compared to data from 12 non-diabetic participants. Spontaneous fetal MEG signals were recorded and power spectral density was computed in four standard frequency bands. Group differences were investigated using analysis of covariance. Our results showed that type 1 group was significantly different (p < 0.05) than the reference group for three of the four brain activity frequency bands, while in type 2, two bands exhibited this trend. When dichotomized based on the maternal glycemic control, significant differences in all bands were observed between the poor-control and reference groups. The fetal background brain activity parameters appear to be altered in diabetic pregnancy in comparison to the reference low-risk group. The study showed that maternal pregestational diabetes could potentially influence in-utero neurodevelopment.
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DOI：
10.1136/archdischild-2013-304283
发表时间：
2013-11
期刊：
Archives of disease in childhood. Fetal and neonatal edition
影响因子：
--
作者：
Castro Conde JR;González González NL;González Barrios D;González Campo C;Suárez Hernández Y;Sosa Comino E
通讯作者：
Sosa Comino E
影响因子：
3.8
作者：
DeBoer, T;Wewerka, S;Nelson, CA
通讯作者：
Nelson, CA
影响因子：
4.7
作者：
Eswaran, Hari;Haddad, Naim I.;Lowery, Curtis L.
通讯作者：
Lowery, Curtis L.
影响因子：
3.8
作者：
SCHER, MS;SUN, MG;SCLABASSI, RJ
通讯作者：
SCLABASSI, RJ
影响因子：
9.8
作者：
Kiefer, Isabelle;Siegel, Eric;Eswaran, Hari
通讯作者：
Eswaran, Hari