Video-EEG recordings in full-term neonates of diabetic mothers: observational study.

Video-EEG recordings in full-term neonates of diabetic mothers: observational study.
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DOI:
10.1136/archdischild-2013-304283
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发表时间:
2013-11
期刊:
Archives of disease in childhood. Fetal and neonatal edition
影响因子:
--
通讯作者:
Sosa Comino E
Sosa Comino E
中科院分区:
其他
文献类型:
--
作者:
Castro Conde JR;González González NL;González Barrios D;González Campo C;Suárez Hernández Y;Sosa Comino E

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To determine whether full-term newborn infants of diabetic mothers (IDM) present immature/disorganised EEG patterns in the immediate neonatal period, and whether there was any relationship with maternal glycaemic control. Cohort study with an incidental sample performed in a tertiary hospital neonatal unit. 23 IDM and 22 healthy newborns born between 2010 and 2013. All underwent video-EEG recording lasting >90 min at 48–72 h of life. We analysed the percentage of indeterminate sleep, transient sharp waves per hour and mature-for-gestational age EEG patterns (discontinuity, maximum duration of interburst interval (IBI), asynchrony, asymmetry, δ brushes, encoches frontales and α/θ rolandic activity). The group of IDM was divided into two subgroups according to maternal HbA1c: (1) HbA1c≥6% and (2) HbA1c<6%. Compared with healthy newborns, IDM presented significantly higher percentage of indeterminate sleep (57% vs 25%; p<0.001), discontinuity (2.5% vs 0%; p=0.044) and δ brushes in the bursts (6% vs 3%; p=0.024); higher duration of IBI (0.3 s vs 0 s; p=0.017); fewer encoches frontales (7/h vs 35/h; p<0.001), reduced θ/α rolandic activity (3/h vs 9/h; p<0.001); and more transient sharp waves (25/h vs 5/h; p<0.001). IDM with maternal HbA1c≥6% showed greater percentage of δ brushes in the burst (14% vs 4%; p=0.007). Full-term IDM newborns showed video-EEG features of abnormal development of brain function. Maternal HbA1c levels<6% during pregnancy could minimise the risk of cerebral dysmaturity.
DOI: 10.1016/j.clinph.2008.12.028
发表时间: 2009-03-01
影响因子: 4.7
作者:
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