Altered Offspring Immunity in Maternal Parasitic Infections.
Altered Offspring Immunity in Maternal Parasitic Infections.
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DOI：
10.4049/jimmunol.2100708
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发表时间：
2022-01-15
期刊：
影响因子：
--
通讯作者：
Fairfax KC
中科院分区：
文献类型：
--
作者：
Gibbs LC;Fairfax KC
众所周知，孕期母体感染会改变后代免疫系统的发育和功能，导致对常见儿童期感染和免疫接种出现不适当的免疫反应。尽管这是一个不断发展的领域，但母体寄生虫感染仍研究不足。目前，数百万育龄妇女面临寄生虫感染的风险，而许多怀孕且长期感染的妇女被排除在大规模药物治疗之外，部分原因是资源匮乏，以及担心对胎儿发育产生未知的不良后果。在多种寄生虫感染流行的地区，如撒哈拉以南非洲，与非流行地区相比，儿童早期各种感染的发病率和死亡率都有所增加。尽管有证据表明不同寄生虫种类之间具有相似的免疫调节作用，但对于母体感染如何重新编程后代的免疫力，尚无清晰的机制性理解。这篇简短的综述将比较几种母体寄生虫感染对后代免疫力的影响。
Maternal infection during pregnancy is known to alter the development and function of offspring’s immune system, leading to inappropriate immune responses to common childhood infections and immunizations. Although this is an expanding field, maternal parasitic infections remain understudied. Millions of women of reproductive age are currently at risk of parasitic infection, while many pregnant, chronically infected women are excluded from mass drug administration due partially to a lack of resources, as well as fear of unknown adverse fetal developmental outcomes. In areas endemic for multiple parasitic infections, such as sub-Saharan Africa, there are increased rates of morbidity and mortality for various infections during early childhood in comparison to non-endemic areas. Despite evidence supporting similar immunomodulatory effects between various parasite species, there is no clear mechanistic understanding of how maternal infection reprograms offspring immunity. This brief review will compare the effects of selected maternal parasitic infections on offspring immunity.
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