Imaging cerebral microbleeds using susceptibility weighted imaging: one step toward detecting vascular dementia.
Imaging cerebral microbleeds using susceptibility weighted imaging: one step toward detecting vascular dementia.
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DOI：
10.1002/jmri.22001
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发表时间：
2010-01
影响因子：
4.4
通讯作者：
Kirsch, Wolff M.
中科院分区：
文献类型：
--
作者：
Ayaz, Muhammad;Boikov, Alexander S.;Haacke, E. Mark;Kido, Daniel K.;Kirsch, Wolff M.
采用磁敏感加权成像（SWI）监测健康对照（HC）和轻度认知障碍（MCI）患者的纵向研究中脑微出血（CMB）数量的变化。在4年的时间内，每年使用SWI在1.5T下对28名HC和75名MCI患者进行成像。使用幅度和相位数据来可视化103名受试者的第一次和最后一次扫描的CMB。初步分析显示，28名HC中没有一人拥有超过三个CMB。在75例MCI患者中，5例受试者在首次和末次扫描中均出现3次以上CMB，而1例受试者仅在末次扫描中出现3次以上出血。在这6名MCI患者中，有5名患者的CMB数量随着时间的推移而增加，所有6名患者都继续发展为进行性认知障碍（PCI）。在6例MCI病例的最后一次扫描中观察到的130个CMB中，大多数直径小于4 mm。SWI可以显示直径约为1 mm的小CMB，该技术可用于纵向跟踪其发展。监测CMB可能是评估患者是否存在导致PCI的微血管疾病的一种手段。
To monitor changes in the number of cerebral microbleeds (CMBs) in a longitudinal study of healthy controls (HC) and mild-cognitively impaired (MCI) patients using susceptibility weighted imaging (SWI). SWI was used to image 28 HC and 75 MCI patients annually at 1.5T over a four-year time period. Magnitude and phase data were used to visualize CMBs for the first and last scans of 103 subjects. Preliminary analysis revealed that none of the 28 HC had more than three CMBs. In the 75 MCI patients, five subjects had more than three CMBs in both first and last scans, while one subject had more than three bleeds only in the last scan. In five of these six MCI patients, the number of CMBs increased over time and all six went on to develop progressive cognitive impairment (PCI). Out of the 130 total CMBs seen in the last scans of the six MCI cases, most were less than 4 mm in diameter. SWI can reveal small CMBs on the order of 1 mm in diameter and this technique can be used to follow their development longitudinally. Monitoring CMBs may be a means by which to evaluate patients for the presence of microvascular disease that leads to PCI.
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