In vitro evaluation of blood plasma coagulation responses to four medical-grade polyurethane polymers.
In vitro evaluation of blood plasma coagulation responses to four medical-grade polyurethane polymers.
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DOI：
10.1177/08853282231191410
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发表时间：
2023-08
影响因子：
2.9
通讯作者：
Siedlecki, Christopher A.
中科院分区：
文献类型：
--
作者：
Nguyen, Lan;Xu, Li-Chong;Yeager, Eric;Weiss, William J.;Siedlecki, Christopher A.
嵌段聚氨酯（PU）嵌段共聚物因其良好的生物相容性和优异的力学性能而广泛应用于植入式心血管医疗器械。更具体地说，在过去的几十年中，PU Biospan MS/0.4被用于心室辅助装置。然而，该产品正在停产，因此有必要寻找一种替代PU生物材料用于心血管器械。评估心脏生物材料的一个重要标准是血液相容性。在这项研究中，我们表征了四种医用级聚氨酯生物材料：Biosspan MS/0.4，BioSpan S，BioSpan 2F和CarboSil 20 80 A的表面性质，包括表面化学，形貌，微相分离结构和润湿性，然后使用牛和人血浆测量血浆凝血反应。结果表明，BioSpan 2F含有大量氟，表面自由能最低，而其他材料的表面含有硅树脂。体外凝血试验表明，与聚苯乙烯对照品相比，这些材料显示出改善的凝血反应，并且所有PU生物材料之间的凝血时间无显著差异。显色试验显示，所有PU材料均导致低FXII接触活化，并且FXII接触活化无显著差异，与血浆凝血反应一致。
Segmented polyurethane (PU) block copolymers are widely used in implantable cardiovascular medical devices due to their good biocompatibility and excellent mechanical properties. More specifically, PU Biospan MS/0.4 was used in ventricular assist devices over the past decades. However, this product is being discontinued and it has become necessary to find an alternative PU biomaterial for application in cardiovascular devices. One important criterion for assessing cardiac biomaterials is blood compatibility. In this study, we characterized the surface properties of four medical-grade PU biomaterials: Biospan MS/0.4, BioSpan S, BioSpan 2F, and CarboSil 20 80A, including surface chemistry, topography, microphase separation structure and wettability, and then measured the blood plasma coagulation responses using bovine and human blood plasma. Results showed that BioSpan 2F contains high amounts of fluorine and has the lowest surface free energy while the other materials have surfaces with silicone present. An in vitro coagulation assay shows that these materials demonstrated improved blood coagulation responses compared to the polystyrene control and there were no significant differences in coagulation time among all PU biomaterials. The chromogenic assay showed all PU materials led to low FXII contact activation, and there were no significant differences in FXII contact activation, consistent with plasma coagulation responses.
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DOI：
10.1016/s0143-7496(96)00009-7
发表时间：
1996-01-01
影响因子：
3.4
作者：
Nakamae, K;Nishino, T;Sudaryanto
通讯作者：
Sudaryanto
DOI：
10.1097/mat.0b013e318239feb4
发表时间：
2012-01
期刊：
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子：
--
作者：
Weiss WJ;Carney EL;Clark JB;Peterson R;Cooper TK;Nifong TP;Siedlecki CA;Hicks D;Doxtater B;Lukic B;Yeager E;Reibson J;Cysyk J;Rosenberg G;Pierce WS
通讯作者：
Pierce WS
影响因子：
5.8
作者：
Xu, Li-Chong;Bauer, James W.;Siedlecki, Christopher A.
通讯作者：
Siedlecki, Christopher A.
影响因子：
2.9
作者：
Liu, Q;Runt, J;Werley, T
通讯作者：
Werley, T
影响因子：
2.9
作者：
Zdrahala, RJ;Zdrahala, IJ
通讯作者：
Zdrahala, IJ