Proteins, platelets, and blood coagulation at biomaterial interfaces.

Proteins, platelets, and blood coagulation at biomaterial interfaces.
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DOI:
10.1016/j.colsurfb.2014.09.040
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发表时间:
2014-12-01
影响因子:
5.8
通讯作者:
Siedlecki, Christopher A.
Siedlecki, Christopher A.
中科院分区:
工程技术2区
文献类型:
--
作者:
Xu, Li-Chong;Bauer, James W.;Siedlecki, Christopher A.

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Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.
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