Single neuron responses underlying face recognition in the human midfusiform face-selective cortex.
Single neuron responses underlying face recognition in the human midfusiform face-selective cortex.
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DOI：
10.1038/s41467-023-41323-5
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发表时间：
2023-09-13
影响因子：
16.6
通讯作者：
Rossion, Bruno
中科院分区：
文献类型：
--
作者：
Quian Quiroga, Rodrigo;Boscaglia, Marta;Jonas, Jacques;Rey, Hernan G.;Yan, Xiaoqian;Maillard, Louis;Colnat-Coulbois, Sophie;Koessler, Laurent;Rossion, Bruno
面孔对社会交往至关重要，而对面孔的识别构成了人类大脑最重要、最具挑战性的功能之一。虽然猴子大脑中的神经元选择性地对人脸做出反应已经记录了几十年，但据报道，通过神经成像，人脸选择性神经激活主要发生在人类的中梭状回。然而，在这种类人猿神经解剖结构中，对人脸产生选择性反应的细胞机制仍然未知。在此，我们报告了5名人类受试者（1名男性，4名女性）在面部选择中梭状回植入脑内微电极，同时观看熟悉和不熟悉的面孔和地点的图片时的单个神经元记录。我们在单个细胞水平上观察到对面孔和地点的类似反应，但对面孔做出反应的神经元数量明显更多，从而为该区域观察到的面孔选择性激活提供了机制解释。虽然单个神经元不会优先对熟悉的面孔做出反应，但总体水平的分析可以一致地确定这些面孔（而不是地点）是否熟悉，仅在最初将刺激识别为面孔后约50毫秒。这些结果为人类大脑中面部处理的神经机制提供了见解。人脸在人脑中的选择性主要是通过神经成像方法来评估的。在这里，作者对人类中梭状回进行了单个神经元的记录，发现对面孔做出反应的神经元数量比对地点做出反应的神经元数量要多。
Faces are critical for social interactions and their recognition constitutes one of the most important and challenging functions of the human brain. While neurons responding selectively to faces have been recorded for decades in the monkey brain, face-selective neural activations have been reported with neuroimaging primarily in the human midfusiform gyrus. Yet, the cellular mechanisms producing selective responses to faces in this hominoid neuroanatomical structure remain unknown. Here we report single neuron recordings performed in 5 human subjects (1 male, 4 females) implanted with intracerebral microelectrodes in the face-selective midfusiform gyrus, while they viewed pictures of familiar and unknown faces and places. We observed similar responses to faces and places at the single cell level, but a significantly higher number of neurons responding to faces, thus offering a mechanistic account for the face-selective activations observed in this region. Although individual neurons did not respond preferentially to familiar faces, a population level analysis could consistently determine whether or not the faces (but not the places) were familiar, only about 50 ms after the initial recognition of the stimuli as faces. These results provide insights into the neural mechanisms of face processing in the human brain. Face selectivity in the human brain has mainly been assessed with neuroimaging methods. Here, the authors perform single-neuron recordings in the human midfusiform gyrus, finding a higher number of neurons responding to faces than to places.
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DOI：
10.1126/science.1194908
发表时间：
2010-11-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Freiwald WA;Tsao DY
通讯作者：
Tsao DY
影响因子：
5.3
作者：
Issa, Elias B.;DiCarlo, James J.
通讯作者：
DiCarlo, James J.
影响因子：
3.2
作者：
Gauthier, I;Tarr, MJ;Anderson, AW
通讯作者：
Anderson, AW
影响因子：
3.6
作者：
Bryant, Katherine L.;Glasser, Matthew F.;Preuss, Todd M.
通讯作者：
Preuss, Todd M.
影响因子：
56.9
作者：
Henson, R;Shallice, T;Dolan, R
通讯作者：
Dolan, R