Temperature sensitivity of negative segregation distortion in Drosophila melanogaster.

Temperature sensitivity of negative segregation distortion in Drosophila melanogaster.
复制标题

果蝇负分离扭曲的温度敏感性。

DOI:
10.1093/genetics/135.3.831
复制
发表时间:
1993
期刊:
影响因子:
3.3
通讯作者:
Hiraizumi,Y
Hiraizumi,Y
中科院分区:
生物学2区
文献类型:
--
作者:
Hiraizumi,Y

文献摘要

参考文献

被引文献

相似文献

以往的研究表明,果蝇SD(Segregation Distorter)系统中的分离畸变方向有时可以逆转,但这种逆转只在较弱的畸变体中发现,而且效果并不大。本研究报告了一个强畸变体SD-72染色体的大负分离畸变。在存在特定X染色体supp-X(SD)的情况下,从SD-72/cn bw雄性动物中回收的SD-72染色体的比例k范围为20 ℃时的0.99至28.5 ℃时的0.11,而对于标准X染色体,k范围为0.99至0.95。温度敏感期为精子发生期。使用的交配系统中,精子供应几乎耗尽,它表明,在高温下的负失真是由于在SD-72染色体的数量绝对减少和cnbw染色体的数量绝对增加恢复。在调整非SD相关的温度效应后,SD-72子代数量的减少量与cn bw子代数量的增加量几乎相同,这表明功能障碍从携带一种同源物的精子细胞切换到携带另一种同源物的精子细胞。负失真需要从根本上修改目前的假设分离失真的机制和可能的修改目前的模型建议,在精子发生过程中的两个同源物的功能障碍的差异恢复的基础上。
Previous work has shown that the direction of segregation distortion in the SD (Segregation Distorter) system in Drosophila melanogaster can sometimes be reversed, but this was found only with rather weak distorters and the effect was not large. The present study reports large negative segregation distortion in a strong distorter, SD-72 chromosome. In the presence of a specific X chromosome, supp-X(SD), the proportion, k, of SD-72 chromosomes recovered from the SD-72/cn bw males ranges from 0.99 at 20 degrees to 0.11 at 28.5 degrees, whereas with a standard-X chromosome, k ranges from 0.99 to 0.95 for the same temperature range. The temperature-sensitive period is during spermiogenesis. Using a mating system in which the sperm supply is nearly exhausted, it was shown that the negative distortion at high temperatures is due to an absolute reduction in the number of SD-72 chromosomes and an absolute increase in the number of cn bw chromosomes recovered. After adjusting for non-SD-related temperature effects, the amount of decrease in the number of SD-72 progeny is nearly the same as the amount of increase in the number of cn bw progeny, suggesting that the dysfunction switches from a spermatid carrying one homolog to one carrying the other. Negative distortion requires a radical revision of current hypotheses for the mechanism of segregation distortion and a possible modification of the current model is suggested, based on differential recovery of dysfunction in the two homologs during spermiogenesis.
影响因子: 11.1
作者:
D. Hartl;Y. Hiraizumi;J. Crow
通讯作者: J. Crow
DOI: 10.1093/genetics/121.2.263
发表时间: 1989
期刊: Genetics
影响因子: 3.3
作者:
Hiraizumi,Y
通讯作者: Hiraizumi,Y
由于黑腹果蝇中的分离扭曲剂导致性别比例扭曲。
DOI: --
发表时间: 1969
期刊: Genetics
影响因子: 3.3
作者:
R. Denell;B. H. Judd;R. H. Richardson
通讯作者: R. H. Richardson
DOI: --
发表时间: 1973
期刊: Genetics
影响因子: 3.3
作者:
D. Hartl
通讯作者: D. Hartl
DOI: --
发表时间: 1980
期刊: Genetics
影响因子: 3.3
作者:
Y. Hiraizumi;Diana W. Martin;Irene A. Eckstrand
通讯作者: Irene A. Eckstrand