Rapid and transient enhancement of thalamic information transmission induced by vagus nerve stimulation
Rapid and transient enhancement of thalamic information transmission induced by vagus nerve stimulation
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迷走神经刺激引起丘脑信息传递的快速和短暂增强
DOI：
10.1088/1741-2552/ab6b84
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发表时间：
2020
影响因子：
4
通讯作者：
Wang, Qi
中科院分区：
文献类型：
--
作者：
Rodenkirch, Charles;Wang, Qi
目的迷走神经刺激(VNS)已被FDA批准为一种治疗多种疾病的长期治疗方法，包括耐药癫痫和抑郁症。我们用信息论的方法研究了迷走神经刺激对感觉相关信息传递的影响。主要结果发现，迷走神经刺激增强了丘脑神经元对刺激中特定动力学特征反应的选择性，导致丘脑棘波传递刺激相关信息的效率和速率显著提高。VNS引起的丘脑感觉处理的改善与丘脑爆发式放电的减少是一致的。重要的是，我们发现VNS引起的感觉加工的增强具有快速的起效和抵消作用，在VNS停止一分钟后完全消失。这些效应的时间尺度表明，与涉及长期神经可塑性的潜在机制相反。我们发现，几种VNS模式(紧张性、标准占空比和快速占空比)都能在感觉处理方面产生类似的改善。仔细观察，我们注意到，由于VNS对感觉加工的影响具有快速的时间尺度，标准占空比VNS导致了一种波动的感觉加工状态，这可能是感知行为的次优状态。在不引起丘脑状态波动的情况下，快速占空比VNS和连续紧张性VNS在丘脑信息传输方面的改善程度与标准占空比VNS相似。这些结果首次证明了利用特定的VNS模式来快速改善感觉加工的可行性，并确认快速占空比和紧张性模式是达到这一目的的最佳模式，同时显示标准占空比VNS会导致丘脑状态的非最佳波动。
ObjectiveVagus nerve stimulation (VNS) has been FDA-approved as a long-term, therapeutic treatment for multiple disorders, including pharmacoresistant epilepsy and depression. Here we elucidate the short-term effects of VNS on sensory processing.ApproachWe employed an information theoretic approach to examine the effects of VNS on thalamocortical transmission of sensory-related information along the somatosensory pathway.Main resultsWe found that VNS enhanced the selectivity of the response of thalamic neurons to specific kinetic features in the stimuli, resulting in a significant increase in the efficiency and rate of stimulus-related information conveyed by thalamic spikes. VNS-induced improvements in thalamic sensory processing coincided with a decrease in thalamic burst firing. Importantly, we found VNS-induced enhancement of sensory processing had a rapid onset and offset, completely disappearing one minute after cessation of VNS. The timescales of these effects indicate against an underlying mechanism involving long-term neuroplasticity. We found several patterns of VNS (tonic, standard duty-cycle, and fast duty-cycle) all induced similar improvements in sensory processing. Under closer inspection we noticed that due to the fast timescale of VNS effects on sensory processing, standard duty-cycle VNS induced a fluctuating sensory processing state which may be sub-optimal for perceptual behavior. Fast duty-cycle VNS and continuous, tonic VNS induced quantitatively similar improvements in thalamic information transmission as standard duty-cycle VNS without inducing a fluctuating thalamic state. Further, we found the strength of VNS-induced improvements in sensory processing increased monotonically with amplitude and frequency of VNS.SignificanceThese results demonstrate, for the first time, the feasibility of utilizing specific patterns of VNS to rapidly improve sensory processing and confirm fast duty-cycle and tonic patterns as optimal for this purpose, while showing standard duty-cycle VNS causes non-optimal fluctuations in thalamic state.
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影响因子：
3
作者：
Spindler, Philipp;Bohlmann, Katja;Schneider, Ulf Christoph
通讯作者：
Schneider, Ulf Christoph
影响因子：
6.6
作者：
Serafini, Gianluca;Gonda, Xenia;Engel-Yeger, Batya
通讯作者：
Engel-Yeger, Batya
癫痫和心力衰竭迷走神经刺激参数选择的经验指南。
影响因子：
5.4
作者：
Musselman,EricD;Pelot,NicoleA;Grill,WarrenM
通讯作者：
Grill,WarrenM
影响因子：
5.6
作者：
Asconapé, JJ;Moore, DD;Duffell, WH
通讯作者：
Duffell, WH
影响因子：
6.6
作者：
Ferrarelli, Fabio;Tononi, Giulio
通讯作者：
Tononi, Giulio