Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues.
Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues.
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DOI：
10.1038/nnano.2016.168
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发表时间：
2016-11
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
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作者：
到目前为止，美国食品和药物管理局(FDA)批准的补铁阿魏酸甘油和其他氧化铁纳米颗粒已被用于治疗缺铁症，作为磁共振成像的造影剂和药物载体。在这里，我们展示了阿魏酸甘油酯对早期乳腺癌的生长以及肺癌肝和肺转移的内在疗效。在体外，腺癌细胞与阿魏酸甘油和巨噬细胞共同孵育后，caspase-3活性增强。暴露于阿魏酸甘油酯的巨噬细胞表现出与促炎Th1型反应相关的mRNA增加。在体内，阿魏酸甘油显著抑制小鼠皮下腺癌的生长。此外，在静脉注射肿瘤细胞攻击之前，静脉注射阿魏酸甘油可以防止肝转移的发生。荧光激活细胞分类(FACS)和组织病理学研究表明，观察到的肿瘤生长抑制伴随着肿瘤组织中促炎症的M1巨噬细胞的增加。我们的研究结果表明，阿魏酸甘油酯可以在标签外应用，以保护肝脏免受转移种子的侵袭，并加强巨噬细胞调节癌症的免疫治疗。
Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast agents for magnetic resonance imaging and as drug carriers. Here, we show an intrinsic therapeutic effect of ferumoxytol on the growth of early mammary cancers, and lung cancer metastases in liver and lungs. In vitro, adenocarcinoma cells co-incubated with ferumoxytol and macrophages showed increased caspase-3 activity. Macrophages exposed to ferumoxytol displayed increased mRNA associated with pro-inflammatory Th1-type responses. In vivo, ferumoxytol significantly inhibited growth of subcutaneous adenocarcinomas in mice. In addition, intravenous ferumoxytol treatment before intravenous tumour cell challenge prevented development of liver metastasis. Fluorescence-activated cell sorting (FACS) and histopathology studies showed that the observed tumour growth inhibition was accompanied by increased presence of pro-inflammatory M1 macrophages in the tumour tissues. Our results suggest that ferumoxytol could be applied ‘off label’ to protect the liver from metastatic seeds and potentiate macrophage-modulating cancer immunotherapies.
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影响因子：
3.2
作者：
Knoebel, Y.;Glei, M.;Pool-Zobel, B. L.
通讯作者：
Pool-Zobel, B. L.
乳腺癌细胞中 Sox2 的表达促进 M2 巨噬细胞招募至肿瘤微环境
影响因子：
9.7
作者：
Mou, Wenjun;Xu, Yingxi;Li, Na
通讯作者：
Li, Na
影响因子：
20.3
作者：
Nie, Guangjun;Chen, Guohua;Ponka, Prem
通讯作者：
Ponka, Prem
影响因子：
11.2
作者：
Hadjipanayis CG;Machaidze R;Kaluzova M;Wang L;Schuette AJ;Chen H;Wu X;Mao H
通讯作者：
Mao H
DOI：
10.1158/1078-0432.ccr-10-3420
发表时间：
2011-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Daldrup-Link HE;Golovko D;Ruffell B;Denardo DG;Castaneda R;Ansari C;Rao J;Tikhomirov GA;Wendland MF;Corot C;Coussens LM
通讯作者：
Coussens LM