Optic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.
Optic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.
复制标题
DOI：
10.1002/brb3.2083
复制
发表时间：
2021-05
影响因子：
3.1
通讯作者：
Nakashima I
中科院分区：
文献类型：
--
作者：
Akaishi T;Himori N;Takeshita T;Fujihara K;Misu T;Takahashi T;Fujimori J;Ishii T;Aoki M;Nakazawa T;Nakashima I
本研究的目的是报道血清抗水通道蛋白4 （AQP4）抗体阳性的视神经脊髓炎谱系障碍（NMOSD）患者眼部轻微创伤与视神经炎的可能关联。在此，我们报告了三例因意外轻微眼外伤而发展为急性视神经炎并伴有视觉障碍的患者，且无眼底异常或眶底骨折。3例患者中有2例在创伤发生前有与NMOSD相一致的神经系统障碍史（如脊髓炎、后脑区综合征）。1例患者迅速接受类固醇脉冲治疗和血浆置换，视力完全恢复。另外两名患者在急性期未得到治疗，在受影响的眼睛中留下了严重视力障碍的后遗症。这些病例提示，血清中有抗AQP4抗体的患者，眼部轻微创伤与随后视神经炎的发生可能存在关联。在这种情况下，避免眼外伤和早期给予类固醇脉冲治疗，以应对外伤后的视神经炎。我们报告了3例血清AQP4‐IgG在轻微创伤后发展为视神经炎的病例。所有患者均出现复发性临床病程，与AQP4‐IgG‐阳性NMOSD相符。一名接受类固醇脉冲治疗的患者完全康复，而其他未接受治疗的患者则没有。
The aim of this study was to report the possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti‐aquaporin‐4 (AQP4) antibody‐positive neuromyelitis optica spectrum disorder (NMOSD). Herein, we present three patients who developed acute optic neuritis with visual disturbances after accidental minor trauma to their eyes, without any fundus abnormality or orbital floor fractures present. Two of the three patients had a preceding history of neurological disturbances compatible with NMOSD (e.g., myelitis, area postrema syndrome) before the occurrence of trauma. One patient was rapidly treated with steroid pulse therapy and plasmapheresis, and he fully recovered visual acuity. The other two, who were left untreated in the acute phase, had sequelae of severe visual disturbances in the affected eyes. These cases suggest possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti‐AQP4 antibodies. Avoiding ocular trauma and early administration of steroid pulse therapy in response to optic neuritis after trauma are desired in such cases. We present three cases with serum AQP4‐IgG who developed optic neuritis after minor traumas. All patients showed relapsing clinical course compatible with AQP4‐IgG‐positive NMOSD. One patient treated with steroid pulse therapy had full recovery, but other untreated patients did not.
登录
查看更多内容
影响因子：
9.9
作者：
Wingerchuk DM;Banwell B;Bennett JL;Cabre P;Carroll W;Chitnis T;de Seze J;Fujihara K;Greenberg B;Jacob A;Jarius S;Lana-Peixoto M;Levy M;Simon JH;Tenembaum S;Traboulsee AL;Waters P;Wellik KE;Weinshenker BG;International Panel for NMO Diagnosis
通讯作者：
International Panel for NMO Diagnosis
影响因子：
14.5
作者：
Takahashi, Toshiyuki;Fujihara, Kazuo;Itoyama, Yasuto
通讯作者：
Itoyama, Yasuto
影响因子：
3.8
作者：
Vorwerk, CK;Zurakowski, D;Dreyer, EB
通讯作者：
Dreyer, EB
影响因子：
2.7
作者：
Eskandarieh, Sharareh;Nedjat, Saharnaz;Sahraian, Mohammad Ali
通讯作者：
Sahraian, Mohammad Ali
影响因子：
4.2
作者：
Kang, Jiunn-Horng;Lin, Herng-Ching
通讯作者：
Lin, Herng-Ching