Transfer Function of Macro-Micro Manipulation on a PDMS Microfluidic Chip

Transfer Function of Macro-Micro Manipulation on a PDMS Microfluidic Chip
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DOI:
10.3390/mi8030080
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发表时间:
2017-03-04
期刊:
影响因子:
3.4
通讯作者:
Kaneko M
Kaneko M
中科院分区:
工程技术3区
文献类型:
--
作者:
Mizoue K;Teramura K;Tsai CH;Kaneko M

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为了在微流体通道中实现快速准确的细胞操作,必须了解其输入-输出关系的真实性质。本文的目的是揭示这种微操作的宏驱动器控制的传递函数。理论模型和实验结果的操纵。二阶传递函数的基础上提出的模型,其中聚二甲基硅氧烷(PDMS)的变形起着重要的作用的操作。实验进行了高达300赫兹的输入频率。从实验结果中观察到的一个有趣的现象是,传递函数的频率响应表现得就像系统中的一阶积分算子。PDMS变形的传递函数的作用进行了讨论的实验确定的参数和建议的模型的基础上。
To achieve fast and accurate cell manipulation in a microfluidic channel, it is essential to know the true nature of its input-output relationship. This paper aims to reveal the transfer function of such a micro manipulation controlled by a macro actuator. Both a theoretical model and experimental results for the manipulation are presented. A second-order transfer function is derived based on the proposed model, where the polydimethylsiloxane (PDMS) deformation plays an important role in the manipulation. Experiments are conducted with input frequencies up to 300 Hz. An interesting observation from the experimental results is that the frequency responses of the transfer function behave just like a first-order integration operator in the system. The role of PDMS deformation for the transfer function is discussed based on the experimentally-determined parameters and the proposed model.
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