Karyopherins in nuclear transport of homeodomain proteins during development.
Karyopherins in nuclear transport of homeodomain proteins during development.
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DOI:
10.1016/j.bbamcr.2011.01.013
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发表时间:
2011-09
期刊:
影响因子:
--
通讯作者:
Tao T
中科院分区:
文献类型:
--
作者:
Ye W;Lin W;Tartakoff AM;Tao T
Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking. The accurate nucleocytoplasmic distribution of these proteins is essential for their functions. We summarize information on a) the roles of karyopherins for import and export of homeoproteins, b) the regulation of their nuclear transport during development, and c) the corresponding complexity of homeoprotein nucleocytoplasmic transport signals.
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