Adverse cardiovascular effects with acute particulate matter and ozone exposures: interstrain variation in mice.
Adverse cardiovascular effects with acute particulate matter and ozone exposures: interstrain variation in mice.
复制标题
急性颗粒物和臭氧暴露的不良心血管效应：小鼠之间的应变变化。
DOI：
10.1289/ehp.10689
复制
发表时间：
2008-08
影响因子：
10.4
通讯作者：
Tankersley, Clarke G.
中科院分区：
文献类型：
--
作者：
Hamade, Ali K.;Rabold, Rkhard;Tankersley, Clarke G.
许多流行病学研究表明，环境颗粒物（PM）水平的增加与心血管发病率和死亡率有关。很少有研究调查共污染物（如臭氧）在这种关联中的作用。此外，PM影响心功能的机制仍不确定。我们假设PM和O3在小鼠中诱导不利的心血管影响，并且这些影响是品系依赖性的。在植入测量心率（HR）和心率变异性（HRV）参数的无线电遥测仪后，我们将C57Bl/6J （B6）、C3H/HeJ （HeJ）和C3H/HeOuJ （OuJ）近交系小鼠依次暴露于过滤空气（FA）、炭黑颗粒（CB）或O3和CB三种不同的每日暴露环境中；CB为536±24 μg/m3；为584±35 ppb（平均值±SE）]。我们观察到由于O3CB暴露，所有菌株的HR和HRV都发生了显著变化，但由于连续FA和CB暴露（FACB）， HR和HRV没有变化。这些数据表明，急性HR和HRV效应主要发生在O3CB暴露期间，尤其是HeJ和OuJ小鼠。例如，HeJ和OuJ小鼠在O3CB暴露期间表现出与明显的心动过缓相关的HRV参数急剧增加。相比之下，B6小鼠的HR反应下降，HRV参数没有可检测到的变化。这些发现表明，就PM-和o3诱导的心脏作用而言，存在重要的种间差异。这种品系间变异表明，遗传因素可能会调节HR调节，以应对急性共污染物暴露并从中恢复。
Increased ambient particulate matter (PM) levels are associated with cardiovascular morbidity and mortality, as shown by numerous epidemiology studies. Few studies have investigated the role of copollutants, such as ozone, in this association. Furthermore, the mechanisms by which PM affects cardiac function remain uncertain. We hypothesized that PM and O3 induce adverse cardiovascular effects in mice and that these effects are strain dependent. After implanting radiotelemeters to measure heart rate (HR) and HR variability (HRV) parameters, we exposed C57Bl/6J (B6), C3H/HeJ (HeJ), and C3H/HeOuJ (OuJ) inbred mouse strains to three different daily exposures of filtered air (FA), carbon black particles (CB), or O3 and CB sequentially [O3CB; for CB, 536 ± 24 μg/m3; for O3, 584 ± 35 ppb (mean ± SE)]. We observed significant changes in HR and HRV in all strains due to O3CB exposure, but not due to sequential FA and CB exposure (FACB). The data suggest that primarily acute HR and HRV effects occur during O3CB exposure, especially in HeJ and OuJ mice. For example, HeJ and OuJ mice demonstrated dramatic increases in HRV parameters associated with marked brady-cardia during O3CB exposure. In contrast, depressed HR responses occurred in B6 mice without detectable changes in HRV parameters. These findings demonstrate that important interstrain differences exist with respect to PM- and O3-induced cardiac effects. This interstrain variation suggests that genetic factors may modulate HR regulation in response to and recuperation from acute copollutant exposures.
登录
查看更多内容
DOI：
10.1164/rccm.200611-1627oc
发表时间：
2007-08-15
影响因子：
24.7
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
通讯作者：
Tang, Chin-Sheng
影响因子：
37.8
作者：
Park, Sung Kyun;O'Neill, Marie S.;Schwartz, Joel
通讯作者：
Schwartz, Joel
DOI：
10.1139/h94-003
发表时间：
1994-03-01
期刊：
CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE
影响因子：
--
作者：
BHAMBHANI, Y;NORRIS, S;BELL, G
通讯作者：
BELL, G
DOI：
10.1165/ajrcmb.22.5.3895
发表时间：
2000-05-01
影响因子：
6.4
作者：
Ohtsuka, Y;Brunson, KJ;Kleeberger, SR
通讯作者：
Kleeberger, SR
DOI：
10.1089/jam.2005.18.1
发表时间：
2005-03-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Schulz, H;Harder, V;Peters, A
通讯作者：
Peters, A