Evidence from pupillometry and fMRI indicates reduced neural response during vicarious social pain but not physical pain in autism
Evidence from pupillometry and fMRI indicates reduced neural response during vicarious social pain but not physical pain in autism
复制标题
来自瞳孔测量和功能磁共振成像的证据表明，自闭症患者在替代性社交疼痛期间神经反应减少，但身体疼痛却没有减少
DOI：
10.1002/hbm.22949
复制
发表时间：
2015
影响因子：
4.8
通讯作者：
Paulus
中科院分区：
文献类型：
--
作者：
Kamp-Becker;Einhäuser;Sommer;Frässle;Jansen;Rademacher;Müller-Pinzler;Gazzola;Paulus
自闭症谱系障碍（ASD）以严重的社会缺陷为特征。参与分享他人情感的神经回路功能障碍解释这些缺陷的观点很有吸引力，但只得到了有限的实验支持。在此，我们评估了一种复杂的关于尴尬的替代社会痛苦的范式，以探讨ASD的社会缺陷是否比目前使用的范式更有效。为此，我们对患有ASD的年轻成年人和匹配的健康对照者进行了瞳孔测量和功能磁共振成像。在一个简单的替代性身体疼痛任务中，两组之间在行为、瞳孔测量和前岛（AIC）和前扣带皮层（ACC）的神经激活方面没有差异。相比之下，处理复杂的替代性社会痛苦对ASD患者在分享他人影响的所有生理指标上的反应都有所降低。因此，AIC内活动的减少可以用社交和情感领域自闭症症状的严重程度来解释。此外，行为反应与对照组中发现的前扣带和前岛皮层活动缺乏对应。相反，ASD的行为反应与海马体活动有关。观察到的分离与临床观察相呼应，即ASD的缺陷在复杂的社会情境中最为明显，而简单的任务可能无法探测到参与分享情感的神经通路的功能障碍。我们的研究结果是高度相关的，因为患有自闭症谱系障碍的人可能保留了分担他人身体痛苦的能力，但在生活中重要的更复杂的情感的替代表现方面仍然存在问题。Hum Brain Mapp， 2015年。©2015 Wiley期刊公司
Autism spectrum disorder (ASD) is characterized by substantial social deficits. The notion that dysfunctions in neural circuits involved in sharing another's affect explain these deficits is appealing, but has received only modest experimental support. Here we evaluated a complex paradigm on the vicarious social pain of embarrassment to probe social deficits in ASD as to whether it is more potent than paradigms currently in use. To do so we acquired pupillometry and fMRI in young adults with ASD and matched healthy controls. During a simple vicarious physical pain task no differences emerged between groups in behavior, pupillometry, and neural activation of the anterior insula (AIC) and anterior cingulate cortex (ACC). In contrast, processing complex vicarious social pain yielded reduced responses in ASD on all physiological measures of sharing another's affect. The reduced activity within the AIC was thereby explained by the severity of autistic symptoms in the social and affective domain. Additionally, behavioral responses lacked correspondence with the anterior cingulate and anterior insula cortex activity found in controls. Instead, behavioral responses in ASD were associated with hippocampal activity. The observed dissociation echoes the clinical observations that deficits in ASD are most pronounced in complex social situations and simple tasks may not probe the dysfunctions in neural pathways involved in sharing affect. Our results are highly relevant because individuals with ASD may have preserved abilities to share another's physical pain but still have problems with the vicarious representation of more complex emotions that matter in life.Hum Brain Mapp, 2015. ©2015 Wiley Periodicals, Inc.
登录
查看更多内容
影响因子：
7.6
作者：
Klin, A
通讯作者：
Klin, A
影响因子：
3.6
作者：
F. Paulus;S. Krach;Marius Blanke;Christine Roth;M. Belke;J. Sommer;Laura Müller-Pinzler;K. Menzler;A. Jansen;F. Rosenow;F. Bremmer;W. Einhäuser;S. Knake
通讯作者：
F. Paulus;S. Krach;Marius Blanke;Christine Roth;M. Belke;J. Sommer;Laura Müller-Pinzler;K. Menzler;A. Jansen;F. Rosenow;F. Bremmer;W. Einhäuser;S. Knake
影响因子：
5.7
作者：
Müller-Pinzler L;Gazzola V;Keysers C;Sommer J;Jansen A;Frässle S;Einhäuser W;Paulus FM;Krach S
通讯作者：
Krach S
影响因子：
5.6
作者：
R. Kana;T. Keller;N. Minshew;V. Cherkassky;M. Just
通讯作者：
R. Kana;T. Keller;N. Minshew;V. Cherkassky;M. Just
替代尴尬中的自主神经激活增加。
影响因子：
3
作者：
Laura Müller;F. Paulus;G. Stemmler;S. Krach
通讯作者：
S. Krach