Adverse Childhood Experience Is Associated With Disrupted White Matter Integrity in Autism Spectrum Disorder: A Diffusion Tensor Imaging Study.
Adverse Childhood Experience Is Associated With Disrupted White Matter Integrity in Autism Spectrum Disorder: A Diffusion Tensor Imaging Study.
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不良的童年经历与自闭症谱系障碍中的白质完整性中断有关：扩散张量成像研究。
DOI：
10.3389/fpsyt.2021.823260
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发表时间：
2021
影响因子：
4.7
通讯作者：
Makinodan M
中科院分区：
文献类型：
--
作者：
Yoshikawa H;Kitamura S;Matsuoka K;Takahashi M;Ishida R;Kishimoto N;Yasuno F;Yasuda Y;Hashimoto R;Miyasaka T;Kichikawa K;Kishimoto T;Makinodan M
自闭症谱系障碍（ASD）患者的不良童年经历（ACE）风险高于正常发育（TD）儿童。由于多项研究表明ACE与额叶的髓鞘形成有关，因此ACE暴露可能与额叶的白色微结构破坏有关，这可能与成年后的精神障碍有关。在这项研究中，我们调查了ACE和额叶相关的白色物质束的微结构完整性之间的关系，使用扩散张量成像在63个ASD和38 TD参与者。使用纤维束成像为基础的分析，我们划定了钩束（UF），背扣带（Ci），丘脑前辐射（ATR），这是参与ASD的神经病理，并估计每个扩散参数。与TD参与者相比，ASD个体在左侧ATR中显示出显著较低的各向异性分数（FA）和较高的径向扩散率（RD）。然后，ASD个体暴露于严重的ACE显示出更高的RD比那些暴露于轻度ACE和TD参与者在左ATR。此外，ACE的严重程度，特别是忽视，与ASD患者的左UF和ATR中FA较低和RD较高相关，而TD参与者中未观察到。这些结果表明，ACE暴露与ASD患者额叶相关白色物质异常有关。
Individuals with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs) than typically developed (TD) children. Since multiple lines of studies have suggested that ACEs are related to myelination in the frontal lobe, an exposure to ACEs can be associated with white matter microstructural disruption in the frontal lobe, which may be implicated in subsequential psychological deficits after the adulthood. In this study, we investigated the relationship between ACEs and microstructural integrity on frontal lobe-related white matter tracts using diffusion tensor imaging in 63 individuals with ASD and 38 TD participants. Using a tractography-based analysis, we delineated the uncinate fasciculus (UF), dorsal cingulum (Ci), and anterior thalamic radiation (ATR), which are involved in the neural pathology of ASD, and estimated each diffusion parameter. Compared to the TD participants, individuals with ASD displayed significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the left ATR. Then, ASD individuals exposed to severe ACEs displayed higher RD than those exposed to mild ACEs and TD participants in the left ATR. Moreover, the severity of ACEs, particularly neglect, correlated with lower FA and higher RD in the left UF and ATR in individuals with ASD, which was not observed in TD participants. These results suggest that an exposure to ACEs is associated with abnormality in the frontal lobe-related white matter in ASD.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
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