Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function.
Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function.
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Ikaros转录因子在淋巴细胞发育和功能中的既定和紧急作用。
DOI：
10.1111/imr.12936
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发表时间：
2021-03
影响因子：
8.7
通讯作者：
Oestreich KJ
中科院分区：
文献类型：
--
作者：
Read KA;Jones DM;Freud AG;Oestreich KJ
Ikaros锌指转录因子是造血细胞谱系发育的基因程序的重要调控因子。该家族由五个成员组成：Ikaros，Helios，Aiolos，Eos和Pegasus，它们参与了同型和异型的家族内相互作用，以发挥不同的功能作用。开创性的研究集中在这些因子在早期淋巴发育中的作用，因为它们的缺乏导致淋巴细胞群的严重缺陷。最近的工作现在已经开始定义Ikaros家族成员在成熟T、B和先天淋巴细胞群体（包括自然杀伤（NK）细胞）的分化和功能中的细微差别、阶段特异性作用。这些因子独立和协同发挥作用的精确转录机制是一个积极研究的领域。然而，几个关键的主题似乎正在出现关于Ikaros家族成员影响的途径，包括细胞因子信号传导的端到端调节。在这里，我们回顾Ikaros因子在淋巴细胞发育，分化和功能中的作用，包括讨论目前对它们所采用的转录机制的理解，以及对这个重要的转录因子家族未来研究的考虑。
Ikaros zinc finger transcription factors are important regulators of the gene programs underlying the development of hematopoietic cell lineages. The family consists of five members: Ikaros, Helios, Aiolos, Eos, and Pegasus, which engage in both homo- and heterotypic intrafamilial interactions to exert diverse functional effects. Pioneering studies focused on the role of these factors in early lymphoid development, as their absence resulted in severe defects in lymphocyte populations. More recent work has now begun to define nuanced, stage-specific roles for Ikaros family members in the differentiation and function of mature T, B, and innate lymphoid cell populations including natural killer (NK) cells. The precise transcriptional mechanisms by which these factors function, both independently and collaboratively, is an area of active investigation. However, several key themes appear to be emerging regarding the pathways influenced by Ikaros family members, including the end-to-end regulation of cytokine signaling. Here, we review roles for Ikaros factors in lymphoid cell development, differentiation, and function, including a discussion of the current understanding of the transcriptional mechanisms they employ, and considerations for the future study of this important transcription factor family.
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