Helios expression is a marker of T cell activation and proliferation.
Helios expression is a marker of T cell activation and proliferation.
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DOI：
10.1371/journal.pone.0024226
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Hancock WW
中科院分区：
文献类型：
--
作者：
Akimova T;Beier UH;Wang L;Levine MH;Hancock WW
Foxp 3+调节性T细胞（T细胞）通常用于减弱免疫应答，并且是维持免疫稳态的关键。在过去的十年中，Treg细胞已经成为许多研究小组的主要研究焦点，并且已经表征了各种功能亚群。最近，Ikaros家族成员Helios被报道为区分天然存在的胸腺源性T细胞与从幼稚CD 4 + T细胞外周诱导的T细胞的标志物。我们研究了Helios在小鼠和人类T细胞中的表达，在静息或活化条件下，使用了良好表征的幼稚/效应/记忆表型分子，以及一组Treg相关标志物。我们发现Helios阴性T细胞富集幼稚T细胞表型，反之亦然。此外，Helios可以在T细胞活化和增殖期间被诱导，但在静息条件下在相同的细胞中消退。我们使用人和鼠CD 4 + Foxp 3 + T细胞以及CD 4+和CD 8 + T细胞证明了相当的结果。由于Helios表达与T细胞活化和细胞分裂相关，无论涉及的细胞亚群如何，它似乎不适合作为区分天然和诱导Treg细胞的标志物。
Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune homeostasis. Over the past decade, Treg cells have become a major focus of research for many groups, and various functional subsets have been characterized. Recently, the Ikaros family member, Helios, was reported as a marker to discriminate naturally occurring, thymic-derived Tregs from those peripherally induced from naïve CD4+ T cells. We investigated Helios expression in murine and human T cells under resting or activating conditions, using well-characterized molecules of naïve/effector/memory phenotypes, as well as a set of Treg-associated markers. We found that Helios-negative T cells are enriched for naïve T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. We demonstrated comparable findings using human and murine CD4+Foxp3+ Tregs, as well as in CD4+ and CD8+ T cells. Since Helios expression is associated with T cell activation and cellular division, regardless of the cell subset involved, it does not appear suitable as a marker to distinguish natural and induced Treg cells.
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DOI：
10.4049/jimmunol.181.4.2855
发表时间：
2008-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Golovina TN;Mikheeva T;Suhoski MM;Aqui NA;Tai VC;Shan X;Liu R;Balcarcel RR;Fisher N;Levine BL;Carroll RG;Warner N;Blazar BR;June CH;Riley JL
通讯作者：
Riley JL
影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
CD127表达与FOXP3和人类CD4+ T Reg细胞的抑制功能成反比。
DOI：
10.1084/jem.20060772
发表时间：
2006-07-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
15.3
作者：
Kimmig, Sonja;Przybylski, Grzegorz K;Schmidt, Christian A;Laurisch, Katja;Mowes, Beate;Radbruch, Andreas;Thiel, Andreas
通讯作者：
Thiel, Andreas
影响因子：
5.4
作者：
Chen, Xin;Subleski, Jeffrey J.;Hamano, Ryoko;Howard, O. M. Zack;Wiltrout, Robert H.;Oppenheim, Joost J.
通讯作者：
Oppenheim, Joost J.