Comparative genome analyses of Mycobacterium avium reveal genomic features of its subspecies and strains that cause progression of pulmonary disease.
Comparative genome analyses of Mycobacterium avium reveal genomic features of its subspecies and strains that cause progression of pulmonary disease.
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DOI：
10.1038/srep39750
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发表时间：
2017-01-03
影响因子：
4.6
通讯作者：
Ogawa K
中科院分区：
文献类型：
--
作者：
Uchiya KI;Tomida S;Nakagawa T;Asahi S;Nikai T;Ogawa K
由非结核分枝杆菌（NTM）引起的肺部疾病在世界范围内日益增加。鸟分枝杆菌是人类和动物中最具临床意义的NTM菌种，包括四个亚种：M。鸟亚种avium（MAA）、M.鸟亚种silvaticum（MAS），M.鸟亚种副结核分枝杆菌（MAP）和M.鸟亚种Hominissuis（MAH）。为了提高对M.禽流感及其在疾病中的作用，我们进行了比较基因组分析的79 M。鸟株我们的分析表明，MAH是一个开放的泛基因组物种。基于单核苷酸变异的系统发育分析表明，MAH在亚种间序列变异程度最高，日本分离株和国外分离株具有明显的系统发育特征。此外，MAP菌株，MAS和MAA菌株分离自鸟类，许多MAH菌株，导致肺部疾病的进展，被分组在每个特定的集群。比较基因组分析揭示了每个谱系特有的遗传元件的存在，这些遗传元件被认为是在进化过程中通过水平基因转移获得的，并确定了解释M的致病性和宿主范围特征的潜在遗传决定因素。avium
Pulmonary disease caused by nontuberculous mycobacteria (NTM) is increasing worldwide. Mycobacterium avium is the most clinically significant NTM species in humans and animals, and comprises four subspecies: M. avium subsp. avium (MAA), M. avium subsp. silvaticum (MAS), M. avium subsp. paratuberculosis (MAP), and M. avium subsp. hominissuis (MAH). To improve our understanding of the genetic landscape and diversity of M. avium and its role in disease, we performed a comparative genome analysis of 79 M. avium strains. Our analysis demonstrated that MAH is an open pan-genome species. Phylogenetic analysis based on single nucleotide variants showed that MAH had the highest degree of sequence variability among the subspecies, and MAH strains isolated in Japan and those isolated abroad possessed distinct phylogenetic features. Furthermore, MAP strains, MAS and MAA strains isolated from birds, and many MAH strains that cause the progression of pulmonary disease were grouped in each specific cluster. Comparative genome analysis revealed the presence of genetic elements specific to each lineage, which are thought to be acquired via horizontal gene transfer during the evolutionary process, and identified potential genetic determinants accounting for the pathogenic and host range characteristics of M. avium.
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DOI：
10.1164/rccm.201111-2016oc
发表时间：
2012-04-15
影响因子：
24.7
作者：
Adjemian, Jennifer;Olivier, Kenneth N.;Prevots, D. Rebecca
通讯作者：
Prevots, D. Rebecca
与痤疮相关的人皮肤微生物组中的痤疮丙酸杆菌菌株群体。
影响因子：
6.5
作者：
Fitz-Gibbon, Sorel;Tomida, Shuta;Chiu, Bor-Han;Lin Nguyen;Du, Christine;Liu, Minghsun;Elashoff, David;Erfe, Marie C.;Loncaric, Anya;Kim, Jenny;Modlin, Robert L.;Miller, Jeff F.;Sodergren, Erica;Craft, Noah;Weinstock, George M.;Li, Huiying
通讯作者：
Li, Huiying
DOI：
10.1126/science.1182395
发表时间：
2010-01-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Harris SR;Feil EJ;Holden MT;Quail MA;Nickerson EK;Chantratita N;Gardete S;Tavares A;Day N;Lindsay JA;Edgeworth JD;de Lencastre H;Parkhill J;Peacock SJ;Bentley SD
通讯作者：
Bentley SD
影响因子：
56.9
作者：
ARRUDA, S;BOMFIM, G;RILEY, LW
通讯作者：
RILEY, LW
DOI：
10.1073/pnas.97.3.1252
发表时间：
2000-02-01
影响因子：
11.1
作者：
De Voss, JJ;Rutter, K;Barry, CE
通讯作者：
Barry, CE