Opportunistic Viral Infections in the Setting of Human Immunodeficiency Virus

Opportunistic Viral Infections in the Setting of Human Immunodeficiency Virus
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人类免疫缺陷病毒环境中的机会性病毒感染

DOI:
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发表时间:
1999
影响因子:
2.7
通讯作者:
D. Clifford
D. Clifford
中科院分区:
医学3区
文献类型:
--
作者:
D. Clifford

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人类免疫缺陷病毒(HIV)感染提供了一个额外的神经问题发展的环境。这些并发症的机制因药物而异,但所遇到的疾病范围的增加对诊断医生提出了挑战,并为深入了解这些疾病及其治疗提供了前所未有的机会。本综述讨论了最突出的病毒相关并发症,进行性多灶性白质脑病除外,这将在另一篇综述中讨论。由于其频率和严重程度,最重要的并发症是由巨细胞病毒引起的,因此我们对这些并发症进行了更深入的讨论。然而,Epstein-Barr病毒与中枢神经系统淋巴瘤诱导的关联代表了一种重要的病毒相关并发症。此外,水痘带状疱疹病毒活性的增加在HIV感染的情况下是显著的。最后,人类疱疹病毒6型是一种新兴的病毒,在HIV感染的背景下被发现,其在病理生理学中的作用现在才被研究。
Human immunodeficiency virus (HIV) infection has provided a setting in which additional neurologic problems develop. The mechanism of these complications varies from agent to agent, but the added spectrum of diseases encountered has challenged diagnosticians and provided unparalleled opportunities to develop a deeper understanding of these conditions and their treatments. This review addresses the most prominent viral-associated complications, except for progressive multifocal leukoencephalopathy, which is addressed in a separate review. The complications of greatest importance both due to their frequency and severity are caused by cytomegalovirus, so these are discussed in greater depth. However, the association of Epstein-Barr virus with induction of central nervous system lymphoma represents an important viral linked complication of great importance. In addition, the increased activity of varicella zoster virus has been notable in the setting of HIV. Finally, human herpesvirus type 6 is an emerging virus of interest that has been identified in the setting of HIV infection, whose role in pathophysiology is only now being investigated.
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