Cytoskeleton dynamics during neurotransmitter release
Cytoskeleton dynamics during neurotransmitter release
复制标题
神经递质释放过程中的细胞骨架动力学
DOI：
10.1016/0166-2236(93)90079-2
复制
发表时间：
1993
影响因子：
15.9
通讯作者：
Vitale Ml
中科院分区：
文献类型：
--
作者：
Trifaró Jm;Vitale Ml
近年来，细胞骨架及其相关蛋白在分泌中起着重要作用。本文综述了细胞骨架组织及其调控蛋白的分子拓扑结构，以及神经元和分泌细胞分泌过程中细胞器发生的动态变化。虽然两个明显不同的超微结构和分子组织的细胞骨架似乎参与神经元和分泌细胞的分泌，有相似之处，这两个系统之间。在神经元和分泌细胞中，Caz+在细胞骨架动力学的控制中起着关键作用，尤其是在分泌过程中观察到的肌动蛋白丝网络的变化中。胞吐过程是细胞成分和分泌囊泡之间的有趣的相互作用。近年来，我们对分泌囊泡膜成分的了解迅速增加1 '2。已经描述了分泌囊泡与诸如钙调蛋白、GTP结合蛋白和细胞骨架组分的组分的相互作用1'2。分泌囊泡的胞吐作用受到高度调节，需要细胞内Ca 2+浓度的增加。虽然这种二价阳离子在分泌中起着关键作用，但Ca 2+在胞吐中的作用位点（或更可能的位点）尚未阐明。然而，在神经分泌细胞的释放位点观察到的细胞骨架的动态变化的调节可能是这些网站的Ca 2+分泌的作用之一。在过去的几年中，对激素和神经递质释放机制的研究表明，Ca 2+确实对分泌过程中的细胞骨架有影响2。最近也已经清楚，细胞骨架及其相关蛋白质在分泌机制中起主要作用2。
It has become apparent in recent years that the cytoskeleton and its associated proteins play a major role in secretion. This review summarizes recent findings on the cytoskeleton organization and the molecular topology of its regulatory proteins, as well as the dynamic changes that occur in this organelle during secretion from neurons and secretory cells. Although two apparently different ultrastructures and molecular organizations of the cytoskeleton seem to be involved in neuronal and secretory cell secretion, there are similarities between the two systems. In both neurons and secretory cells, Ca z+ plays a pivotal role in the control of cytoskeleton dynamics, especially in the changes in actin filament networks observed during secretion.The process of exocytosis is a fascinating interplay between the cellular components and secretory vesicles. Our knowledge of the membrane components of the secretory vesicles has increased rapidly in recent years 1'2. Interactions of secretory vesicles with components such as calmodulin, GTP-binding proteins and cytoskeletal components have been described 1'2. The exocytosis of secretory vesicles is highly regulated and requires an increase in the intracellular Ca 2+ concentration. Although this divalent cation plays a pivotal role in secretion, the site (or more probably the sites) of action for Ca 2+ in exocytosis has not yet been elucidated. However, one of these sites of action for Ca 2+ in secretion might be the regulation of the dynamic changes in the cytoskeleton observed at release sites in neurosecretory cells. During the past few years, studies on the mechanisms of hormone and neurotransmitter release have suggested that Ca 2+ does indeed have an effect on the cytoskeleton during secretion 2. It has also become clear recently that the cytoskeleton and its associated proteins play a major role in the mechanisms of secretion 2.
蛋白激酶 C 磷酸化神经丝蛋白。
影响因子：
3.5
作者：
Sihag,RK;Jeng,AY;Nixon,RA
通讯作者：
Nixon,RA
影响因子：
56.9
作者：
GREENGARD, P;VALTORTA, F;BENFENATI, F
通讯作者：
BENFENATI, F
影响因子：
56.9
作者：
BRADY, ST;LASEK, RJ;ALLEN, RD
通讯作者：
ALLEN, RD