Spatially restricting gene expression by local translation at synapses.
Spatially restricting gene expression by local translation at synapses.
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DOI：
10.1016/j.tins.2010.01.005
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发表时间：
2010-04
影响因子：
15.9
通讯作者：
Zukin, R. Suzanne
中科院分区：
文献类型：
--
作者：
Wang, Dan Ohtan;Martin, Kelsey C.;Zukin, R. Suzanne
mRNA localization and regulated translation provide a means of spatially restricting gene expression within each of the thousands of subcellular compartments made by a neuron, thereby vastly increasing the computational capacity of the brain. Recent studies reveal that local translation is regulated by stimuli that trigger neurite outgrowth/collapse, axon guidance, synapse formation, pruning, activity-dependent synaptic plasticity, and injury induced axonal regeneration. Impairments in the local regulation of translation result in aberrant signaling, physiology, and morphology of neurons, and are linked to neurological disorders. This review highlights current advances in understanding how mRNAs are translationally repressed during transport and how local translation is activated by stimuli. We address the function of local translation in the context of fragile X mental retardation.
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