Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity.
Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity.
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DOI：
10.1016/j.bone.2009.11.011
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发表时间：
2010-03
期刊：
影响因子：
4.1
通讯作者：
Boskey, Adele L.
中科院分区：
文献类型：
--
作者：
Gourion-Arsiquaud, Samuel;Allen, Matthew R.;Burr, David B.;Vashishth, Deepak;Tang, Simon Y.;Boskey, Adele L.
骨丢失和骨质量改变是导致绝经后妇女骨脆性的主要原因。虽然众所周知，双膦酸盐在绝经后骨质疏松症中可以减少骨转换和防止骨丢失，但它们对其他骨特性的影响还没有完全确定。骨矿物质和基质性质的变化可能有助于观察到双膦酸类药物的抗骨折疗效。这项工作的目的是分析低剂量和高剂量阿仑膦酸盐或利塞膦酸盐为期一年的治疗对空间分辨骨材料和成分特性的影响，这些材料和成分特性可能有助于这些制剂的骨折疗效。用傅里叶变换红外成像(FTIRI)对30只正常比格犬胫骨远端进行了傅立叶变换红外成像(FTIRI)分析，以评估离散骨区矿物质和基质性质的变化。每个FTIRI参数的像素直方图的一半最大宽度被用来评估骨组织的异质性。ALN和Ris主要增加松质骨和皮质内表面的矿物质含量和胶原成熟度。骨组织中的矿物含量和羟基磷灰石结晶度分布存在显著差异，这可能导致延展性降低和微裂纹堆积。低剂量和高剂量之间以及Aln和Ris处理之间没有显著差异。这些结果表明，在骨转换较高的正常松质骨和皮质内骨区域，药物抑制骨转换可增加矿物质和基质骨组织成熟度。这些降低骨折风险的积极作用也与骨异质性的丧失有关，这可能是导致骨组织脆性增加和微裂纹堆积的一个因素。
Bone loss and alterations in bone quality are major causes leading to bone fragility in postmenopausal women. Although bisphosphonates are well known to reduce bone turnover and prevent bone loss in postmenopausal osteoporosis, their effects on other bone properties are not fully characterized. Changes in bone mineral and matrix properties may contribute to the anti-fracture efficacy observed with bisphosphonate treatments. The aim of this work was to analyze the effect of a one-year treatment with either alendronate or risedronate, at low and high doses, on spatially resolved bone material and compositional properties that could contribute to the fracture efficacy of these agents. Distal tibias from thirty normal beagles that had been treated daily for one year with oral doses of vehicle (Veh), alendronate (Aln) at 0.2 or 1 mg/kg, and risedronate (Ris) at 0.1 or 0.5 mg/kg were analyzed by Fourier Transform Infrared imaging (FTIRI) to assess the changes in both mineral and matrix properties in discrete bone areas. The widths at half maximum of the pixel histograms for each FTIRI parameter were used to assess the heterogeneity of the bone tissue. Aln and Ris increased the mineral content and the collagen maturity mainly in cancellous bone and at the endocortical surface. Significant differences were observed in the mineral content and in the hydroxyapatite crystallinity distribution in bone tissue, which can contribute to reduced ductility and micro-crack accumulation. No significant differences were observed between low and high dose nor between Aln and Ris treatments. These results show that pharmacologic suppression of bone turnover increases the mineral and matrix bone tissue maturity in normal cancellous and endocortical bone areas where bone turnover is higher. These positive effects for decreased fracture risk are also associated with a loss of bone heterogeneity that could be one factor contributing to increased bone tissue brittleness and micro-crack accumulation.
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影响因子：
2.8
作者：
Day, JS;Ding, M;Weinans, H
通讯作者：
Weinans, H
影响因子：
6.2
作者：
Durchschlag, Erich;Paschalis, Eleftherios P.;Klaushofer, Klaus
通讯作者：
Klaushofer, Klaus
影响因子：
2.4
作者：
Currey, JD;Brear, K;Zioupos, P
通讯作者：
Zioupos, P
双膦酸盐的风险和益处。
影响因子：
8.8
作者：
Coleman, R. E.
通讯作者：
Coleman, R. E.
影响因子：
4.3
作者：
Bouxsein, Mary L;Karasik, David
通讯作者：
Karasik, David