Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients.

Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients.
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验证Promis身体机能测量的癌症患者队列中各种各样的人群。

DOI:
10.1007/s11136-015-0992-9
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发表时间:
2015-10
影响因子:
3.5
通讯作者:
Moinpour, Carol M.
Moinpour, Carol M.
中科院分区:
医学2区
文献类型:
--
作者:
Jensen, Roxanne E.;Potosky, Arnold L.;Reeve, Bryce B.;Hahn, Elizabeth;Cella, David;Fries, James;Smith, Ashley Wilder;Keegan, Theresa H. M.;Wu, Xiao-Cheng;Paddock, Lisa;Moinpour, Carol M.

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评价患者报告结局测量信息系统(PROMIS)身体功能测量在多样化、基于人群的癌症样本中的有效性。诊断后6-13个月的癌症患者(n= 4,840)被招募用于测量您的健康(MY-Health)研究。参与者在2010-2013年期间被诊断患有非霍奇金淋巴瘤或结肠直肠癌,肺癌,乳腺癌,子宫癌,宫颈癌或前列腺癌。评估了四种PROMIS身体功能简表(4a、6 b、10a和16)在不同年龄和种族群体中的有效性和可靠性。协变量包括性别、婚姻状况、教育水平、癌症部位和分期、合并症和功能状态。PROMIS身体功能简表在调查简表、年龄和种族间显示出较高的内部一致性(Cronbach α =0.92 - 0.96)、收敛效度(疲劳、疼痛干扰、FACT身体健康均r≥0.68)和判别效度(不相关领域均r≤0.3)。根据假设进行的人口统计学、临床和功能特征的已知组差异。在大多数形式中,确定了高功能个体的上限效应。本研究提供了强有力的证据,证明PROMIS身体功能测量在多个种族-民族和年龄组中有效且可靠。选择特定PROMIS简表的研究人员应考虑其患者人群的功能残疾程度,以确保长度和内容适合限制应答负担。
To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function measures in a diverse, population-based cancer sample. Cancer patients 6–13 months post diagnosis (n=4,840) were recruited for the Measuring Your Health (MY-Health) study. Participants were diagnosed between 2010–2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS Physical Function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race-ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. PROMIS Physical Function short forms showed high internal consistency (Cronbach’s α =0.92 – 0.96), convergent validity (Fatigue, Pain Interference, FACT Physical Well-Being all r≥0.68) and discriminant validity (unrelated domains all r≤0.3) across survey short forms, age, and race-ethnicity. Known group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. This study provides strong evidence that PROMIS Physical Function measures are valid and reliable in multiple race-ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.
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