Repetition of letter strings leads to activation of and connectivity with word-related regions.
Repetition of letter strings leads to activation of and connectivity with word-related regions.
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DOI：
10.1016/j.neuroimage.2011.09.047
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发表时间：
2012-02-01
期刊：
影响因子：
5.7
通讯作者：
Tagamets, Malle A.
中科院分区：
文献类型：
--
作者：
Fisher, Joscelyn E.;Cortes, Carlos R.;Griego, Jacqueline A.;Tagamets, Malle A.
个体通过逐渐识别重复的字母组合来学习阅读。然而，目前尚不清楚与重复基本刺激（如字母串）相关的神经机制如何或何时转移到高阶语言网络的参与。本研究通过在一小时的时间内反复呈现不熟悉的字母串来调查这个问题。激活模式表明，只有与视觉处理相关的大脑区域在早期被激活，但在刺激变得更加熟悉之后，通常与额下回语义和语音处理相关的其他区域被激活。在双侧上颞叶皮层也观察到激活的变化，这也暗示了向更基于语言的处理策略的转变。连通性分析揭示了两个不同的网络对应于语音和视觉处理，这可能反映了间接和直接的阅读途径。在整个实验过程中，语音通路保持着相似程度的连通性，而随着刺激变得更加熟悉，视觉区域与语言区域的连通性增加，这表明直接通路在早期就被吸收了。这项研究提供了关于个体熟悉不熟悉的字母组合（即新语言中的单词，新的首字母缩写）时大脑可塑性的见解，并对在语言补救疗法的开发过程中参与这些语言网络具有启示意义。
Individuals learn to read by gradually recognizing repeated letter combinations. However, it is unclear how or when neural mechanisms associated with repetition of basic stimuli (i.e., strings of letters) shift to involvement of higher-order language networks. The present study investigated this question by repeatedly presenting unfamiliar letter strings in a one-back matching task during an hour-long period. Activation patterns indicated that only brain areas associated with visual processing were activated during the early period, but additional regions that are usually associated with semantic and phonological processing in inferior frontal gyrus were recruited after stimuli became more familiar. Changes in activation were also observed in bilateral superior temporal cortex, also suggestive of a shift toward a more language-based processing strategy. Connectivity analyses reveal two distinct networks that correspond to phonological and visual processing, which may reflect the indirect and direct routes of reading. The phonological route maintained a similar degree of connectivity throughout the experiment, whereas visual areas increased connectivity with language areas as stimuli became more familiar, suggesting early recruitment of the direct route. This study provides insight about plasticity of the brain as individuals become familiar with unfamiliar combinations of letters (i.e., words in a new language, new acronyms) and has implications for engaging these linguistic networks during development of language remediation therapies.
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影响因子：
3.2
作者：
Devlin, Joseph T.;Jamison, Helen L.;Gonnerman, Laura M.;Matthews, Paul M.
通讯作者：
Matthews, Paul M.
影响因子：
3.4
作者：
James, Karin H.;Atwood, Thea P.
通讯作者：
Atwood, Thea P.
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1002/9780470757642.ch1
发表时间：
2005-01-01
期刊：
SCIENCE OF READING: A HANDBOOK
影响因子：
--
作者：
Coltheart, Max
通讯作者：
Coltheart, Max
影响因子：
5.7
作者：
Jobard, G;Crivello, F;Tzourio-Mazoyer, N
通讯作者：
Tzourio-Mazoyer, N