Evidence for neurogenesis within the white matter beneath the temporal neocortex of the adult rat brain
Evidence for neurogenesis within the white matter beneath the temporal neocortex of the adult rat brain
复制标题
成年大鼠大脑颞叶新皮质下方白质内神经发生的证据
DOI：
10.1016/j.neuroscience.2005.04.033
复制
发表时间：
2005
期刊：
影响因子：
3.3
通讯作者：
N. Takemura
中科院分区：
文献类型：
--
作者：
N. Takemura
成人中枢神经系统中持续的神经元产生（成人神经发生）涉及各种脑功能，如学习/记忆和情绪控制。尽管神经干/祖细胞广泛存在，但活跃的成体神经发生仅在两个有限的区域中建立。在这项研究中，我们探索了一个以前被忽视的成年大鼠大脑中的神经原区域，并检测到皮层下白色物质中神经元产生的证据。分裂Pax 6-和Olig 2-阳性神经前体细胞在该区域不断产生doublecortin阳性的新神经元。然而，绝大多数新生神经元在出生后一周内就丢失了。累积的凋亡细胞表明该区域中正在进行的细胞死亡。除了提供新生细胞迁移到海马的证据，这些结果表明，细胞的发生，死亡和迁移坚持在成人白色物质的一个有限的子区域。
Persistent neuron production in the adult CNS (adult neurogenesis) has been implicated in various brain functions such as learning/memory and mood control. Despite the widespread occurrence of neural stem/progenitor cells, active adult neurogenesis has been established only in two restricted regions. We explored in this study a previously overlooked neurogenic region in the adult rat brain and detected the evidence of neuron production within the subcortical white matter. Dividing Pax6- and Olig2-positive neural progenitor cells continually gave rise to doublecortin-positive new neurons in this region. However, the vast majority of newborn neurons were lost within a week of their birth. Accumulated apoptotic cells indicated the ongoing cell death in this area. In addition to providing the evidence of newborn cell migration to the hippocampus, these results suggest that cell genesis, death, and migration persist in a restricted subregion of the adult white matter.
影响因子：
56.9
作者：
Gould, E;Reeves, AJ;Gross, CG
通讯作者：
Gross, CG
DOI：
10.1073/pnas.90.5.2074
发表时间：
1993-03-01
影响因子：
11.1
作者：
LOIS, C;ALVAREZBUYLLA, A
通讯作者：
ALVAREZBUYLLA, A