Epidemiology and classification of dry eye.

Epidemiology and classification of dry eye.
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干眼症的流行病学和分类。

DOI:
--
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发表时间:
1998
影响因子:
--
通讯作者:
M. Lemp
M. Lemp
中科院分区:
医学4区
文献类型:
--
作者:
M. Lemp

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干眼症或干燥性角结膜炎(KCS)是一种以眼前泪膜紊乱导致眼表疾病为特征的多种临床疾病状态。1 KCS占眼科医生就诊患者的很高比例,其治疗在美国产生了每年超过1亿美元的医药市场(行业估计)。目前约有700万至1000万美国人需要使用人工泪液。2 KCS与多种眼部症状相关,从轻度短暂刺激到持续刺激、烧灼感、瘙痒、发红、疼痛、眼疲劳和视力障碍。3,4在更严重的形式中,干燥综合征相关KCS与威胁视力的并发症相关,包括巩膜炎,角膜溃疡和继发性细菌感染。5病理生理因素包括泪液生成不足、泪液成分的质的变化、眼睑睑板腺油脂分泌的改变、眨眼异常和眼表的炎性变化。6
Dry eye, or keratoconjunctivitis sicca (KCS), is a rubric for a number of clinical disease states characterized by disturbances in the pre-ocular tear film resulting in ocular surface disease.1 KCS accounts for a high percentage of patient visits to ophthalmologists, and its treatment has given rise to a pharmaceutical market in the US of over $100 million per year (industry estimates). Approximately 7–10 million Americans currently require the use of artificial tear preparations.2 KCS is associated with a broad spectrum of ocular symptoms ranging from mild transient irritation to persistent irritation, burning, itchiness, redness, pain, ocular fatigue, and vision disturbances.3,4 In its more severe form, Sjogren’s-associated KCS, it is associated with vision-threatening complications including scleritis, corneal ulceration, and secondary bacterial infection.5 Pathophysiologic factors include deficiencies in aqueous tear production, qualitative changes in tear composition, alterations in the oil secretion of the meibomian glands of the eyelids, blinking abnormalities, and inflammatory changes in the ocular surface.6
DOI: 10.4049/jimmunol.137.10.3162
发表时间: 1986-11
影响因子: 4.4
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R. Fox;G. Pearson;J. Vaughan
通讯作者: R. Fox;G. Pearson;J. Vaughan
DOI: 10.1016/s0161-6420(90)32372-2
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DOI: 10.1016/0166-0934(88)90049-3
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DOI: --
发表时间: 1985
期刊: Journal of immunology (Baltimore, Md. : 1950)
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DOI: --
发表时间: 1987
期刊: Rheumatic diseases clinics of North America
影响因子: --
作者:
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