Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae.
Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae.
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DOI：
10.1111/php.13389
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发表时间：
2021-07
影响因子：
3.3
通讯作者：
Cheng JX
中科院分区：
文献类型：
--
作者：
Jusuf S;Dong PT;Hui J;Ulloa ER;Liu GY;Cheng JX
无乳链球菌，也称为B族链球菌（GBS），越来越多地被认为是老年人和糖尿病人群中软组织和侵袭性疾病的主要原因。青霉素等抗生素被频繁用于治疗这些感染，尽管GBS菌株中的抗菌素耐药性正在增加，并强调需要不依赖传统抗生素的替代方法。GBS石榴皮色素与GBS的溶血素/溶细胞素有关，这在GBS疾病的发病机制中至关重要。在这里，我们表明，光漂白granadaene抑制GBS的溶血活性。此外，发现这种抗氧化剂的光漂白增加GBS对活性氧物种如过氧化氢的杀伤的敏感性。用光处理也显示影响GBS膜渗透性，并有助于增加对细胞膜靶向达托霉素的敏感性。总的来说，我们的研究证明了光漂白对GBS的毒力和抗菌药物敏感性的双重影响，并提出了一种治疗GBS感染的新方法。
Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is increasingly recognized as a major cause of soft tissue and invasive diseases in the elderly and diabetic populations. Antibiotics like penicillin are used with great frequency to treat these infections, although antimicrobial resistance is increasing among GBS strains and underlines a need for alternative methods not reliant on traditional antibiotics. GBS granadaene pigment is related to the hemolysin/cytolysin of GBS, which is critical for the pathogenesis of GBS diseases. Here, we show that photobleaching granadaene dampens the hemolytic activity of GBS. Furthermore, photobleaching of this antioxidant was found to increase GBS susceptibility to killing by reactive oxygen species like hydrogen peroxide. Treatment with light was also shown to affect GBS membrane permeability and contribute to increased susceptibility to the cell membrane-targeting daptomycin. Overall, our study demonstrates a dual effect of photobleaching on the virulence and antimicrobial susceptibility of GBS and suggests a novel approach for the treatment of GBS infection.1
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影响因子：
3.6
作者：
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DOI：
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