Comparative and parallel genome-wide association studies for metabolic and agronomic traits in cereals.
Comparative and parallel genome-wide association studies for metabolic and agronomic traits in cereals.
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谷物代谢和农艺性状的比较和平行全基因组关联研究
DOI：
10.1038/ncomms12767
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发表时间：
2016-10-04
影响因子：
16.6
通讯作者：
Luo, Jie
中科院分区：
文献类型：
--
作者：
Chen, Wei;Wang, Wensheng;Peng, Meng;Gong, Liang;Gao, Yanqiang;Wan, Jian;Wang, Shouchuang;Shi, Lei;Zhou, Bin;Li, Zongmei;Peng, Xiaoxi;Yang, Chenkun;Qu, Lianghuan;Liu, Xianqing;Luo, Jie
植物代谢组具有广泛的多样性，被认为是连接基因组和表型组的桥梁。在这里，我们报告的代谢和表型全基因组的研究（mGWAS和pGWAS）在水稻籽粒，除了以前的代谢GWAS在水稻叶片和玉米籽粒，显示不同的和重叠的方面的遗传控制的代谢内和物种之间。我们确定了新的候选基因可能影响重要的代谢和/或形态性状。我们发现，水稻不同组织间代谢的差异遗传结构部分是由组织特异性表达决定的。使用平行的mGWAS和pGWAS，我们确定了新的候选基因可能负责的性状，如籽粒颜色和大小的变化，并提供了代谢型-表型连锁的证据。我们的研究为植物功能基因组学和代谢组学的研究提供了一个强有力的策略，特别是对复杂表型性状的微效QTL的克隆。 植物代谢组常被认为是连接基因组变异和表型变异的桥梁。在这里，作者在水稻籽粒中进行了代谢和表型全基因组关联研究，并与之前对水稻叶片和玉米籽粒的研究进行了比较，以展示一种研究复杂性状的新策略。
The plant metabolome is characterized by extensive diversity and is often regarded as a bridge between genome and phenome. Here we report metabolic and phenotypic genome-wide studies (mGWAS and pGWAS) in rice grain that, in addition to previous metabolic GWAS in rice leaf and maize kernel, show both distinct and overlapping aspects of genetic control of metabolism within and between species. We identify new candidate genes potentially influencing important metabolic and/or morphological traits. We show that the differential genetic architecture of rice metabolism between different tissues is in part determined by tissue specific expression. Using parallel mGWAS and pGWAS we identify new candidate genes potentially responsible for variation in traits such as grain colour and size, and provide evidence of metabotype-phenotype linkage. Our study demonstrates a powerful strategy for interactive functional genomics and metabolomics in plants, especially the cloning of minor QTLs for complex phenotypic traits. The plant metabolome is often considered as a bridge between genomic and phenotypic variation. Here, the authors perform metabolic and phenotypic genome-wide association studies in rice grain, and compare to prior studies on rice leaf and maize kernel, to demonstrate a new strategy to investigate complex traits.
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影响因子：
30.8
作者：
Keurentjes, Joost J. B.;Fu, Jingyuan;Koornneef, Maarten
通讯作者：
Koornneef, Maarten
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影响因子：
27.5
作者：
Chen, Wei;Gong, Liang;Luo, Jie
通讯作者：
Luo, Jie
影响因子：
46.9
作者：
Fiehn, O;Kopka, J;Willmitzer, L
通讯作者：
Willmitzer, L
影响因子：
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作者：
Du, Yegang;Chu, Hung;Lo, Clive
通讯作者：
Lo, Clive
非靶向代谢组学揭示粳稻和籼稻品种之间的代谢差异。
影响因子：
4.6
作者：
Hu C;Shi J;Quan S;Cui B;Kleessen S;Nikoloski Z;Tohge T;Alexander D;Guo L;Lin H;Wang J;Cui X;Rao J;Luo Q;Zhao X;Fernie AR;Zhang D
通讯作者：
Zhang D