Association of malnutrition with geriatric assessment impairments and health-related quality of life among older adults with gastrointestinal malignancies.
Association of malnutrition with geriatric assessment impairments and health-related quality of life among older adults with gastrointestinal malignancies.
复制标题
胃肠道恶性肿瘤的老年人的营养不良与老年评估障碍和与健康相关的生活质量的关联。
作者：
Williams GR;Al-Obaidi M;Dai C;Mir N;Challa SA;Daniel M;Patel H;Barlow B;Young-Smith C;Gbolahan O;Paluri R;Bhatia S;Giri S
大多数患有癌症的老年人会出现营养不良;然而，人们对其在这一弱势群体中的影响知之甚少。我们的目的是量化营养相关症状和营养不良的患病率与胃肠道（GI）恶性肿瘤的老年人及其与老年评估（GA）功能障碍，健康相关的生活质量（HRQOL），和医疗保健利用。对转诊至伯明翰亚拉巴马大学GI肿瘤诊所的老年人（≥60岁）进行的横断面研究。参与者接受了癌症与衰老复原力评估（CARE）调查，其中包括简化的患者生成的主观全球营养评估（abPG-SGA）。营养评分分为正常（0-5）和营养不良（≥6），多变量分析，调整人口统计学，癌症类型和癌症分期，以检查与GA损伤，HRQOL和医疗保健利用的关联。共纳入336名受试者，平均年龄为70 ± 7.2岁，56.8%为男性，最常见的诊断为结直肠癌（33.6%）和胰腺癌（24.4%）。总体而言，52.1%的参与者被确定为营养不良。营养不良与几种GA损伤的较高患病率相关，包括≥1次福尔斯（校正比值比[aOR] = 2.1）、工具性日常生活活动（iADL）损伤（aOR = 4.1）和虚弱（aOR 8.2）。营养不良也与HRQOL领域受损相关;身体（aOR = 8.7）和精神（aOR = 5.0）以及既往住院（aOR = 2.2）。我们发现患有GI恶性肿瘤的老年人营养不良的患病率很高，这与GA损伤增加，HRQOL降低和医疗保健利用增加有关。超过一半（52.1%）的老年胃肠道恶性肿瘤患者营养不良，食欲不振和早饱是最常见的营养相关症状。营养不良与几种GA损伤的患病率较高相关，包括≥1次福尔斯、工具性日常生活活动障碍和虚弱，以及健康相关生活质量降低和既往住院。
A majority of older adults with cancer develop malnutrition; however, its implications among this vulnerable population is poorly understood. We aimed to quantify the prevalence of nutrition related-symptoms and malnutrition among older adults with gastrointestinal (GI) malignancies and its association with geriatric assessment (GA) impairment, health-related quality of life (HRQOL), and healthcare utilization. Cross-sectional study of older adults (≥60 years) who were referred to the GI Oncology clinic at the University of Alabama at Birmingham. Participants underwent the Cancer & Aging Resilience Evaluation (CARE) survey that includes the abbreviated Patient-Generated Subjective Global Assessment (abPG-SGA) of nutrition. Nutrition scores were dichotomized into normal (0–5) and malnourished (≥6), and multivariate analyses, adjusting for demographics, cancer type, and cancer stage were used to examine associations with GA impairment, HRQOL and healthcare utilization. 336 participants were included, with mean age of 70 ± 7.2y, 56.8% male, with colorectal (33.6%) and pancreatic cancer (24.4%) being the most common diagnoses. Overall, 52.1% of participant were identified as malnourished. Malnutrition was associated with a higher prevalence of several GA impairments including ≥1 falls (adjusted odds ratio [aOR] = 2.1), instrumental Activities of Daily Living (iADL) impairment (aOR = 4.1), and frailty (aOR 8.2). Malnutrition was also associated with impaired HRQOL domains; both physical (aOR = 8.7) and mental (aOR = 5.0), and prior hospitalizations (aOR = 2.2). We found a high prevalence of malnutrition among older adults with GI malignancies that was associated with increased GA impairments, reduced HRQOL, and increased healthcare utilization. Over half (52.1%) of older adults with gastrointestinal malignancies were malnourished with poor appetite and early satiety the most common nutrition related symptoms. Malnutrition was associated with a higher prevalence of several GA impairments including ≥1 falls, instrumental Activities of Daily Living impairment, and frailty, as well as reduced health-related quality life and prior hospitalizations.
登录
查看更多内容
影响因子：
6.3
作者：
Arends, Jann;Bachmann, Patrick;Preiser, Jean-Charles
通讯作者：
Preiser, Jean-Charles
影响因子：
2.5
作者：
Chabowski, Mariusz;Polanski, Jacek;Rosinczuk, Joanna
通讯作者：
Rosinczuk, Joanna
影响因子：
6.2
作者：
de Pinho, Nivaldo B.;Martucci, Renata B.;Peres, Wilza A. F.
通讯作者：
Peres, Wilza A. F.
影响因子：
6.2
作者：
Extermann, Martine;Boler, Ivette;Balducci, Lodovico
通讯作者：
Balducci, Lodovico
DOI：
10.1080/01635581.2013.755554
发表时间：
2013-02-01
影响因子：
2.9
作者：
Gabrielson, Denise K.;Scaffidi, Donna;Darling, Pauline B.
通讯作者：
Darling, Pauline B.