Won't You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity.
Won't You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity.
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DOI：
10.3389/fcell.2022.887107
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
上皮组织形成连续的屏障来保护免受外部环境的侵害。在这些组织中，上皮细胞构建面向环境的根尖膜，将相邻细胞固定在一起的连接复合物，以及面向其他细胞的底外侧表面。关键的是，为了形成一个连续的顶端屏障，邻近的上皮细胞必须对齐它们的顶-底外侧轴，以沿着整个组织形成全局极性。在这里，我们将回顾全局组织水平极性建立的机制，重点关注不同来源的相邻上皮细胞如何排列其顶端表面。具有不同发育起源和/或在不同时间和地点极化的上皮细胞必须排列其各自的顶基底轴。将不同的上皮组织连接成连续的薄片或管，称为上皮融合，在相邻细胞最初停靠在根尖到根尖界面的情况下被广泛研究。然而，上皮细胞也可以从基底到基底，这对根尖的连续性提出了一些挑战。组织之间原有的基底膜必须被重塑和/或移除，参与对接的细胞被特化，新的细胞-细胞粘连形成。这些挑战都可能涉及上皮细胞顶基底侧极性的改变。这篇综述重点介绍了几个体内基底对接的例子，以及上皮融合过程中顶-基底侧极性的变化。了解基底对接的特定分子机制是一个成熟的领域，可以进一步探索，这将揭示塑造发育生物体的复杂形态发生事件，以及在涉及囊肿、瘘管、闭锁和转移形成的疾病期间可能出错的细胞机制。
Epithelial tissues form continuous barriers to protect against external environments. Within these tissues, epithelial cells build environment-facing apical membranes, junction complexes that anchor neighbors together, and basolateral surfaces that face other cells. Critically, to form a continuous apical barrier, neighboring epithelial cells must align their apico-basolateral axes to create global polarity along the entire tissue. Here, we will review mechanisms of global tissue-level polarity establishment, with a focus on how neighboring epithelial cells of different origins align their apical surfaces. Epithelial cells with different developmental origins and/or that polarize at different times and places must align their respective apico-basolateral axes. Connecting different epithelial tissues into continuous sheets or tubes, termed epithelial fusion, has been most extensively studied in cases where neighboring cells initially dock at an apical-to-apical interface. However, epithelial cells can also meet basal-to-basal, posing several challenges for apical continuity. Pre-existing basement membrane between the tissues must be remodeled and/or removed, the cells involved in docking are specialized, and new cell-cell adhesions are formed. Each of these challenges can involve changes to apico-basolateral polarity of epithelial cells. This minireview highlights several in vivo examples of basal docking and how apico-basolateral polarity changes during epithelial fusion. Understanding the specific molecular mechanisms of basal docking is an area ripe for further exploration that will shed light on complex morphogenetic events that sculpt developing organisms and on the cellular mechanisms that can go awry during diseases involving the formation of cysts, fistulas, atresias, and metastases.
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DOI：
10.1038/nrdp.2015.7
发表时间：
2015-04-30
期刊：
Nature reviews. Disease primers
影响因子：
--
作者：
Copp AJ;Adzick NS;Chitty LS;Fletcher JM;Holmbeck GN;Shaw GM
通讯作者：
Shaw GM
DOI：
10.1073/pnas.1808760115
发表时间：
2018-11-06
影响因子：
11.1
作者：
Cáceres R;Bojanala N;Kelley LC;Dreier J;Manzi J;Di Federico F;Chi Q;Risler T;Testa I;Sherwood DR;Plastino J
通讯作者：
Plastino J
影响因子：
5.3
作者：
Gestri G;Bazin-Lopez N;Scholes C;Wilson SW
通讯作者：
Wilson SW
DOI：
10.1002/dvdy.24219
发表时间：
2015-03
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
--
作者：
Billmyre KK;Hutson M;Klingensmith J
通讯作者：
Klingensmith J
影响因子：
2.7
作者：
Georgas, Kylie;Rumballe, Bree;Little, Melissa H.
通讯作者：
Little, Melissa H.