Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD.
Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD.
复制标题
无症状AD风险个体认知能力下降轨迹的认识
DOI：
10.1186/s13195-020-00700-8
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发表时间：
2020-10-14
期刊：
影响因子：
--
通讯作者：
INSIGHT-PreAD study group
中科院分区：
文献类型：
--
作者：
Cacciamani F;Sambati L;Houot M;Habert MO;Dubois B;Epelbaum S;INSIGHT-PreAD study group
缺乏对认知衰退（ACD）的认识在晚期阿尔茨海默病（AD）中很常见。最近的研究表明，ACD也可以在早期阶段减少。我们描述了一组记忆抱怨者3年来ACD的不同演变趋势及其与淀粉样蛋白负担和脑代谢的关系。我们研究了基线时ACD对认知评分演变的影响，以及ACD与认知评分的纵向变化之间的关系。76.8%的受试者持续准确的ACD（参考类）。18.95%的患者ACD稳定升高，在人口统计学特征和AD生物标志物方面与准确ACD的患者相当。4.25%的患者持续表现为低ACD，淀粉样蛋白负荷明显高于参考组，且以男性为主。我们发现基线ACD对认知评分的演变没有总体影响，ACD的纵向变化与认知评分之间没有关联。在一组个体的临床前阶段，ACD开始减少，这是非常有趣的，需要进一步表征。本研究是INSIGHT-PreAD研究的一部分。INSIGHT-PreAD研究（ID-RCB）的识别号为2012-A01731-42。
Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer’s disease (AD). Recent studies showed that ACD can also be reduced in the early stages. We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores’ evolution and the association between longitudinal changes in ACD and in cognitive score. 76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ACD, had significantly higher amyloid burden than the reference class, and were mostly men. We found no overall effect of baseline ACD on cognitive scores’ evolution and no association between longitudinal changes in ACD and in cognitive scores. ACD begins to decrease during the preclinical phase in a group of individuals, who are of great interest and need to be further characterized. The present study was conducted as part of the INSIGHT-PreAD study. The identification number of INSIGHT-PreAD study (ID-RCB) is 2012-A01731-42.
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