Rumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial.
Rumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial.
复制标题
DOI：
10.1016/j.bpsgos.2023.08.012
复制
发表时间：
2024-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
以反刍思维为中心的认知行为疗法（RF-CBT）旨在减少抑郁性反刍思维或以重复、消极、被动和全面的方式沉迷于经历的习惯性倾向。 RF-CBT 使用功能分析、体验式练习和重复练习来识别和改变反刍习惯。这项预注册的随机临床试验（NCT03859297，R61）是初始工作的预注册复制。我们假设左后扣带皮层与右额下回和颞下回之间的自我报告的沉思和跨网络连接同时减少。 76 名有抑郁史和沉思过多的青少年被随机分配接受 10 至 14 次 RF-CBT（n = 39；34 名完成者）或照常治疗（n = 37；28 名完成者）。意向治疗分析评估了反刍反应量表的前后变化，以及使用两次 5 分钟、12 秒的静息态功能磁共振成像评估的功能连接性。我们重复了之前的研究结果：与照常接受治疗的参与者相比，接受 RF-CBT 的参与者的沉思反应量表显着减少，左后扣带皮层到右额下回/颞下回的连接也减少。减少幅度很大（z 变化分别 = 0.84；0.73 [ps < .05]）。这项青少年临床试验进一步表明，抑郁性沉思是一种基于大脑的机制，可以通过 RF-CBT 进行修改。在这里，我们重复了 RF-CBT 减少了跨网络连接，这是一种可能的机制，通过这种机制，沉思变得不那么频繁、强烈和自动化。这项由美国国家心理健康研究所资助的快速失败研究继续进行到 R33 阶段，在此期间将比较 RF-CBT 的治疗特异性效果与放松疗法。
Rumination-focused cognitive behavioral therapy (RF-CBT) is designed to reduce depressive rumination or the habitual tendency to dwell on experiences in a repetitive, negative, passive, and global manner. RF-CBT uses functional analysis, experiential exercises, and repeated practice to identify and change the ruminative habit. This preregistered randomized clinical trial (NCT03859297, R61) is a preregistered replication of initial work. We hypothesized a concurrent reduction of both self-reported rumination and cross-network connectivity between the left posterior cingulate cortex and right inferior frontal and inferior temporal gyri. Seventy-six youths with a history of depression and elevated rumination were randomized to 10 to 14 sessions of RF-CBT (n = 39; 34 completers) or treatment as usual (n = 37; 28 completers). Intent-to-treat analyses assessed pre-post change in rumination response scale and in functional connectivity assessed using two 5 minute, 12 second runs of resting-state functional magnetic resonance imaging. We replicated previous findings: a significant reduction in rumination response scale and a reduction in left posterior cingulate cortex to right inferior frontal gyrus/inferior temporal gyrus connectivity in participants who received RF-CBT compared with those who received treatment as usual. Reductions were large (z change = 0.84; 0.73, respectively [ps < .05]). This adolescent clinical trial further demonstrates that depressive rumination is a brain-based mechanism that is modifiable via RF-CBT. Here, we replicated that RF-CBT reduces cross-network connectivity, a possible mechanism by which rumination becomes less frequent, intense, and automatic. This National Institute of Mental Health-funded fast-fail study continues to the R33 phase during which treatment-specific effects of RF-CBT will be compared with relaxation therapy.
登录
查看更多内容
影响因子：
10.6
作者：
Kross, Ethan;Davidson, Matthew;Weber, Jochen;Ochsner, Kevin
通讯作者：
Ochsner, Kevin
影响因子：
--
作者：
Jo HJ;Gotts SJ;Reynolds RC;Bandettini PA;Martin A;Cox RW;Saad ZS
通讯作者：
Saad ZS
影响因子：
4.7
作者：
Bessette KL;Jenkins LM;Skerrett KA;Gowins JR;DelDonno SR;Zubieta JK;McInnis MG;Jacobs RH;Ajilore O;Langenecker SA
通讯作者：
Langenecker SA
影响因子：
17.7
作者：
Dunlop, Boadie W.;LoParo, Devon;Craighead, W. Edward
通讯作者：
Craighead, W. Edward
影响因子：
3.2
作者：
Denson, Thomas F.;Pedersen, William C.;Nandy, Anirvan S.
通讯作者：
Nandy, Anirvan S.