Reliability, Convergent Validity and Time Invariance of Default Mode Network Deviations in Early Adult Major Depressive Disorder.
Reliability, Convergent Validity and Time Invariance of Default Mode Network Deviations in Early Adult Major Depressive Disorder.
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DOI：
10.3389/fpsyt.2018.00244
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发表时间：
2018
影响因子：
4.7
通讯作者：
Langenecker SA
中科院分区：
文献类型：
--
作者：
Bessette KL;Jenkins LM;Skerrett KA;Gowins JR;DelDonno SR;Zubieta JK;McInnis MG;Jacobs RH;Ajilore O;Langenecker SA
关于重度抑郁障碍的默认模式网络(DMN)连通性的研究有很大的变异性，可靠性和时不变性没有报道。本研究评估缓解性抑郁症(RMDD)的DMN连接障碍是否随着时间的推移和症状的非依赖性而可靠，并探索与抑郁症认知特征的趋同关系。对82名没有服用精神药物的年轻人(47名rMDD，35名健康对照)进行了一项纵向研究，他们完成了两个研究地点的临床结构化访谈、神经心理学评估和2次静息状态fMRI扫描。在重复测量方差分析的两个时间点对双侧后扣带回和前海马结构的DMN种子进行功能连通性分析，以比较组和评价组水平连通性结果的可靠性。RMDD的11个高连接簇(来自后扣带)和6个低连接簇(来自海马结构)，除1个簇外，其余所有簇都具有中等到足够的可靠性(ICC的范围为0.50~0.76，其中16个簇的ICC范围为0.50~0.76)。通过主成分分析(得到5个成分)来探索这些连通性成分，并将其与认知特征(沉思、认知控制、学习和记忆、外显情绪识别)相关联。在探索水平上，对于收敛效度，rMDD中由后扣带回和认知控制网络超连通性组成的成分与认知控制(反向)和冥想(正)相关。由具有社会情绪网络的海马前结构和DMN连接不足组成的成分与记忆(反向)和快乐情绪识别(正)相关。因此，时间不变的DMN连接性差异在抑郁症的生命过程中早期存在，并且是可靠的。细微差别的结果表明，腹侧网络内连接不足与记忆力差有关，背侧跨网络连接过度连接与认知控制能力差和沉思增加有关。对早期病程缓解性抑郁症的研究，注意可靠性和症状独立性，可能会导致更容易翻译的生物标记物临床评估工具。
There is substantial variability across studies of default mode network (DMN) connectivity in major depressive disorder, and reliability and time-invariance are not reported. This study evaluates whether DMN dysconnectivity in remitted depression (rMDD) is reliable over time and symptom-independent, and explores convergent relationships with cognitive features of depression. A longitudinal study was conducted with 82 young adults free of psychotropic medications (47 rMDD, 35 healthy controls) who completed clinical structured interviews, neuropsychological assessments, and 2 resting-state fMRI scans across 2 study sites. Functional connectivity analyses from bilateral posterior cingulate and anterior hippocampal formation seeds in DMN were conducted at both time points within a repeated-measures analysis of variance to compare groups and evaluate reliability of group-level connectivity findings. Eleven hyper- (from posterior cingulate) and 6 hypo- (from hippocampal formation) connectivity clusters in rMDD were obtained with moderate to adequate reliability in all but one cluster (ICC's range = 0.50 to 0.76 for 16 of 17). The significant clusters were reduced with a principle component analysis (5 components obtained) to explore these connectivity components, and were then correlated with cognitive features (rumination, cognitive control, learning and memory, and explicit emotion identification). At the exploratory level, for convergent validity, components consisting of posterior cingulate with cognitive control network hyperconnectivity in rMDD were related to cognitive control (inverse) and rumination (positive). Components consisting of anterior hippocampal formation with social emotional network and DMN hypoconnectivity were related to memory (inverse) and happy emotion identification (positive). Thus, time-invariant DMN connectivity differences exist early in the lifespan course of depression and are reliable. The nuanced results suggest a ventral within-network hypoconnectivity associated with poor memory and a dorsal cross-network hyperconnectivity linked to poorer cognitive control and elevated rumination. Study of early course remitted depression with attention to reliability and symptom independence could lead to more readily translatable clinical assessment tools for biomarkers.
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影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
--
作者：
Jo HJ;Gotts SJ;Reynolds RC;Bandettini PA;Martin A;Cox RW;Saad ZS
通讯作者：
Saad ZS
影响因子：
6.6
作者：
Chen, Yu;Wang, Chun;Zhong, Yuan
通讯作者：
Zhong, Yuan
影响因子：
6.6
作者：
Cao, Xiaohua;Liu, Zhifen;Zhang, Kerang
通讯作者：
Zhang, Kerang
DOI：
10.1016/j.jbtep.2013.07.009
发表时间：
2014-03-01
影响因子：
1.8
作者：
Connolly, Samantha L.;Wagner, Clara A.;Alloy, Lauren B.
通讯作者：
Alloy, Lauren B.