The RESTRICTION checkpoint: a window of opportunity governing developmental transitions in Toxoplasma gondii.
The RESTRICTION checkpoint: a window of opportunity governing developmental transitions in Toxoplasma gondii.
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DOI：
10.1016/j.mib.2020.09.009
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发表时间：
2020-12
影响因子：
5.4
通讯作者：
Suvorova ES
中科院分区：
文献类型：
--
作者：
Sinai AP;Suvorova ES
弓形虫生活史的特征是活跃复制与静止期交替。被包囊的休眠子孢子和迟缓子作为速殖子和裂殖子启动活跃的复制。在这里，我们探讨了细胞周期的作用，重点是典型的G1期限制检查点（R点）作为整合剂，在T。刚地。这种允许复制的监督机制在G1期为细胞重组创造了一个机会窗口，以执行发育过渡。我们还探讨了缓殖子的独特地位，唯一的生命周期阶段执行一个向前（进入性周期）和反向（复发）的发展过渡作为一个多能细胞。这些相反的决定通过限制检查点的共同机制执行。
The life cycle of Toxoplasma gondii is characterized by active replication alternating with periods of rest. Encysted dormant sporozoites and bradyzoites initiate active replication as tachyzoites and merozoites. Here we explore the role of the cell cycle with a focus on the canonical G1 RESTRICTION checkpoint (R-point) as the integrator governing developmental decisions in T. gondii. This surveillance mechanism which licenses replication, creates a window of opportunity in G1 for cellular reorganization in the execution of developmental transitions. We also explore the unique status of the bradyzoite, the only life cycle stage executing both a forward (entry into the sexual cycle) and reverse (recrudescence) developmental transitions as a multipotent cell. These opposing decisions are executed through the common machinery of the RESTRICTION checkpoint.
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影响因子：
4.4
作者：
Hehl AB;Basso WU;Lippuner C;Ramakrishnan C;Okoniewski M;Walker RA;Grigg ME;Smith NC;Deplazes P
通讯作者：
Deplazes P
影响因子：
3.1
作者：
BOHNE, W;HEESEMANN, J;GROSS, U
通讯作者：
GROSS, U
影响因子：
4
作者：
Dubey, JP
通讯作者：
Dubey, JP
影响因子：
30.3
作者：
Krishnan, Aarti;Kloehn, Joachim;Soldati-Favre, Dominique
通讯作者：
Soldati-Favre, Dominique
影响因子：
2.1
作者：
Denton, H;Roberts, CW;Coombs, GH
通讯作者：
Coombs, GH