Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound.
Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound.
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药用植物天然化合物番泻苷 A 的药理学、毒理学和代谢
DOI：
10.3389/fphar.2021.714586
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发表时间：
2021
影响因子：
5.6
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Le J;Ji H;Zhou X;Wei X;Chen Y;Fu Y;Ma Y;Han Q;Sun Y;Gao Y;Wu H
番泻叶皂苷A(Sennoside A，SA)是一种主要来源于番泻属和大黄属药用植物的天然二萜糖苷，是民间传统的刺激性泻药和减肥保健食品。越来越多的证据表明，SA具有泻药、减肥、降血糖、保肝、抗纤维化、抗炎、抗肿瘤、抗细菌、抗真菌、抗病毒、抗神经退行性变等多种药理活性。这些药理作用为其在治疗多种疾病中的潜在应用奠定了基础。然而，大量已发表的研究表明，长期大剂量使用SA可能会产生一些不良反应，包括结肠黑变病的发生和结肠癌的发生，从而限制了其临床应用。SA或其代谢物是否对其药理和毒性作用负责仍有待确定。本文从SA的生物学特性和作用机制入手，综述了SA的药理、毒理和代谢方面的最新研究进展。
Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.
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DOI：
10.2169/internalmedicine.6104-20
发表时间：
2021
期刊：
Internal medicine (Tokyo, Japan)
影响因子：
--
作者：
Kawamoto R;Kikuchi A;Ninomiya D;Kumagi T
通讯作者：
Kumagi T
DOI：
10.1016/s1383-5742(02)00007-8
发表时间：
2002-06-01
影响因子：
5.3
作者：
Bendesky, A;Menéndez, D;Ostrosky-Wegman, P
通讯作者：
Ostrosky-Wegman, P
具核梭杆菌通过调节KRT7-AS/KRT7促进结直肠癌转移
影响因子：
12.2
作者：
Chen, Shujie;Su, Tingting;Wang, Liangjing
通讯作者：
Wang, Liangjing
影响因子：
4.1
作者：
Al-Ghamdi, Areej Dhawi;Zaheer, Zoya;Aazam, Elham Shafik
通讯作者：
Aazam, Elham Shafik
影响因子：
2.9
作者：
Chen, XL;Valente, JF;Alexandre, JW
通讯作者：
Alexandre, JW