Structure and Antimicrobial Activity of Rare Lactone Lipids from the Sooty Mold (Scorias spongiosa).
Structure and Antimicrobial Activity of Rare Lactone Lipids from the Sooty Mold (Scorias spongiosa).
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DOI：
10.1021/acs.jnatprod.1c01012
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发表时间：
2022-05-27
影响因子：
5.1
通讯作者：
Hamann, Mark T.
中科院分区：
文献类型：
--
作者：
Schumacher, Robert W.;Waters, Amanda L.;Peng, Jiangnan;Schumacher, Richard A.;Bateman, Ailish;Thiele, Josie;Mitchell, Andrew J.;Miller, Samuel G.;Goldberg, Arthur;Tripathi, Siddharth K.;Agarwal, Ameeta K.;Zou, Yike;Choo, Yeun-Mun;Hamann, Mark T.
Two new lactone lipids, scoriosin (1) and its methyl ester (2), with a rare furylidene ring joined to a tetrahydrofurandione ring, were isolated from Scorias spongiosa, commonly referred to as sooty mold. The planar structure of these compounds was assigned by 1D and 2D NMR. The conformational analysis of these molecules was undertaken to evaluate the relative and absolute configuration through GIAO NMR chemical shift analysis and ECD calculation. In addition to the potent antimicrobial activities, compound 2 strongly potentiated the activity of amphotericin B against Cryptococcus neoformans, suggesting the potential utility of this compound in combination therapies for treating cryptococcal infections.
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影响因子：
3
作者：
Mayer, Alejandro M. S.;Rodriguez, Abimael D.;Berlinck, Roberto G. S.;Hamann, Mark T.
通讯作者：
Hamann, Mark T.
影响因子：
3.3
作者：
Johansson, M;Köpcke, B;Sterner, O
通讯作者：
Sterner, O
影响因子：
3.3
作者：
Lee, HJ;Lee, JH;Lee, JJ
通讯作者：
Lee, JJ
影响因子：
8.8
作者：
Cho, Jun-Young;Sohn, Mi-Jin;Kim, Won-Gon
通讯作者：
Kim, Won-Gon
影响因子：
2.2
作者：
Krohn, K;Sohrab, H;Schulz, B
通讯作者：
Schulz, B