Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study.
Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study.
复制标题
DOI：
10.1038/s41380-022-01836-9
复制
发表时间：
2023-02
影响因子：
11
通讯作者：
Maes, Michael
中科院分区：
文献类型：
--
作者：
Al-Hakeim, Hussein Kadhem;Al-Rubaye, Haneen Tahseen;Al-Hadrawi, Dhurgham Shihab;Almulla, Abbas F.;Maes, Michael
使用峰值体温（PBT）和外周血氧饱和度（SpO 2）评估的COVID-19急性期的免疫炎症反应可预测3-4个月后慢性疲劳、抑郁和焦虑症状的严重程度。本研究旨在研究急性感染期间SpO 2和PBT对Long COVID的免疫、氧化和亚硝化应激（IO&NS）通路和神经精神症状的影响。本研究测定了120名长期COVID患者和36名对照者在急性COVID-19期间的SpO 2和PBT，以及C反应蛋白（CRP）、丙二醛（MDA）、蛋白质羰基（PC）、髓过氧化物酶（MPO）、一氧化氮（NO）、锌和谷胱甘肽过氧化物酶（Gpx）。聚类分析显示，31.7%的Long COVID患者存在SpO 2、体温严重异常，氧化毒性（OSTOX）增加和抗氧化防御（ANTIOX）降低，总汉密尔顿抑郁（HAMD）和焦虑（HAMA）以及纤维肌松-疲劳（FF）评分增加。长期COVID的神经精神症状（从HAMD、HAMA和FF评分中提取的一个因素）中约60%的变异可由OSTOX/ANTIOX比值、PBT和SpO 2解释。PBT升高预示CRP升高、ANTIOX和锌水平降低，而SpO 2降低预示Gpx降低、NO生成增加。SpO 2降低强烈预测长期COVID期间的OSTOX/ANTIOX。总之，急性COVID-19对长期COVID症状的影响部分由OSTOX/ANTIOX介导，特别是Gpx和锌降低，MPO和NO产生增加以及脂质过氧化物相关的醛形成。结果表明，病毒感染后的躯体和精神症状具有神经免疫和神经氧化起源。
The immune-inflammatory response during the acute phase of COVID-19, as assessed using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the severity of chronic fatigue, depression and anxiety symptoms 3–4 months later. The present study was performed to examine the effects of SpO2 and PBT during acute infection on immune, oxidative and nitrosative stress (IO&NS) pathways and neuropsychiatric symptoms of Long COVID. This study assayed SpO2 and PBT during acute COVID-19, and C-reactive protein (CRP), malondialdehyde (MDA), protein carbonyls (PCs), myeloperoxidase (MPO), nitric oxide (NO), zinc, and glutathione peroxidase (Gpx) in 120 Long COVID individuals and 36 controls. Cluster analysis showed that 31.7% of the Long COVID patients had severe abnormalities in SpO2, body temperature, increased oxidative toxicity (OSTOX) and lowered antioxidant defenses (ANTIOX), and increased total Hamilton Depression (HAMD) and Anxiety (HAMA) and Fibromylagia-Fatigue (FF) scores. Around 60% of the variance in the neuropsychiatric symptoms of Long COVID (a factor extracted from HAMD, HAMA and FF scores) was explained by OSTOX/ANTIOX ratio, PBT and SpO2. Increased PBT predicted increased CRP and lowered ANTIOX and zinc levels, while lowered SpO2 predicted lowered Gpx and increased NO production. Lowered SpO2 strongly predicts OSTOX/ANTIOX during Long COVID. In conclusion, the impact of acute COVID-19 on the symptoms of Long COVID is partly mediated by OSTOX/ANTIOX, especially lowered Gpx and zinc, increased MPO and NO production and lipid peroxidation-associated aldehyde formation. The results suggest that post-viral somatic and mental symptoms have a neuroimmune and neuro-oxidative origin.
登录
查看更多内容
肺炎，降低氧饱和百分比和免疫激活之间的相互作用介导了抑郁症，焦虑和慢性疲劳综合征，因为COVID-19引起的类似于-19的症状：一种名义上的网络方法。
影响因子：
6.6
作者：
Al-Jassas HK;Al-Hakeim HK;Maes M
通讯作者：
Maes M
影响因子：
13.6
作者：
Dotan A;David P;Arnheim D;Shoenfeld Y
通讯作者：
Shoenfeld Y
影响因子：
4
作者：
Debevec T;Millet GP;Pialoux V
通讯作者：
Pialoux V
DOI：
10.1016/s2213-2600(21)00383-0
发表时间：
2021-11
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Evans RA;McAuley H;Harrison EM;Shikotra A;Singapuri A;Sereno M;Elneima O;Docherty AB;Lone NI;Leavy OC;Daines L;Baillie JK;Brown JS;Chalder T;De Soyza A;Diar Bakerly N;Easom N;Geddes JR;Greening NJ;Hart N;Heaney LG;Heller S;Howard L;Hurst JR;Jacob J;Jenkins RG;Jolley C;Kerr S;Kon OM;Lewis K;Lord JM;McCann GP;Neubauer S;Openshaw PJM;Parekh D;Pfeffer P;Rahman NM;Raman B;Richardson M;Rowland M;Semple MG;Shah AM;Singh SJ;Sheikh A;Thomas D;Toshner M;Chalmers JD;Ho LP;Horsley A;Marks M;Poinasamy K;Wain LV;Brightling CE;PHOSP-COVID Collaborative Group
通讯作者：
PHOSP-COVID Collaborative Group
影响因子：
13.8
作者：
Bellan M;Soddu D;Balbo PE;Baricich A;Zeppegno P;Avanzi GC;Baldon G;Bartolomei G;Battaglia M;Battistini S;Binda V;Borg M;Cantaluppi V;Castello LM;Clivati E;Cisari C;Costanzo M;Croce A;Cuneo D;De Benedittis C;De Vecchi S;Feggi A;Gai M;Gambaro E;Gattoni E;Gramaglia C;Grisafi L;Guerriero C;Hayden E;Jona A;Invernizzi M;Lorenzini L;Loreti L;Martelli M;Marzullo P;Matino E;Panero A;Parachini E;Patrucco F;Patti G;Pirovano A;Prosperini P;Quaglino R;Rigamonti C;Sainaghi PP;Vecchi C;Zecca E;Pirisi M
通讯作者：
Pirisi M