The autonomic aspects of the post-COVID19 syndrome.
The autonomic aspects of the post-COVID19 syndrome.
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DOI：
10.1016/j.autrev.2022.103071
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发表时间：
2022-05
影响因子：
13.6
通讯作者：
Shoenfeld Y
中科院分区：
文献类型：
--
作者：
Dotan A;David P;Arnheim D;Shoenfeld Y
SARS-CoV-2爆发导致了COVID-19的广泛传播，导致了现代最严重的流行病之一，但大流行的主要影响可能仍在我们面前。SARS-CoV-2被发现具有自身免疫特性。近20种靶向神经系统GPCR和肾素-血管紧张素系统相关分子的不同自身抗体被发现与COVID-19的临床严重程度显著相关。新的发病超过10种不同的自身免疫性疾病也被记录在案。此外，在许多最近康复的COVID-19患者中引发了持续症状的临床表现，这导致了新术语“COVID-19后综合征”的形成。在约50-80%的有症状的COVID-19患者中，存在与COVID-19后综合征相关的表现，并且在报告了50多种SARS-CoV-2感染的长期影响的患者中。COVID 19后综合征的许多常见症状不能仅用病毒相关损伤来解释。与慢性疲劳综合征和纤维肌痛类似，自身免疫介导的自主神经系统功能障碍可能在这些症状的发病机制中起重要作用，包括慢性疲劳、认知障碍、情绪相关障碍等。重要的是，免疫调节和免疫抑制治疗等治疗选择可能有利于一些COVID 19后患者，而血浆置换和IVIG可以在严重病例中考虑。尽管如此，由于体育锻炼已被发现可以稳定自主神经系统，运动疗法可能是治疗COVID 19后综合征的更安全，更有效的疗法。
The SARS-CoV-2 outbreak, responsible for the widespread COVID-19, led to one of the most rogue pandemics in modern time, yet the major effects of the pandemic may still be ahead of us. SARS-CoV-2 had been found to possess autoimmune properties. Close to 20 distinct autoantibodies which target GPCR of the nervous system and renin-angiotensin system-related molecules were found significantly associated with the clinical severity of COVID-19. The new on-set of more than 10 various autoimmune disorders were documented as well. Additionally, clinical presentations of persisted symptoms were triggered in numerous recently recovered COVID-19 patients, which led to the formulation of the novel term “post-COVID19 syndrome”. Manifestations related to post-COVID-19 syndrome exist among approximately 50–80% of symptomatic COVID-19 patients who recovered, and among patients reported more than 50 different long-term effects of the SARS-CoV-2 infection. Many of the common symptoms of the post-COVID19 syndrome are not explained by the virus-related injury alone. Similarly to chronic fatigue syndrome and fibromyalgia, autoimmune-mediated autonomic nervous system dysfunction may play a significant part in the pathogenesis of such symptoms, including chronic fatigue, cognitive impairment, mood related disorders, and numerous more. Importantly, therapeutic options such as immunomodulatory and immunosuppressive therapy may favor some post-COVID19 patients, while plasmapheresis and IVIG could be considered in severe cases. Nevertheless, as physical exercise has been found to stabilize the autonomic nervous system, exercise therapy might be a safer and more effective remedy for the post-COVID19 syndrome.
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影响因子：
5.5
作者：
Borba V;Malkova A;Basantsova N;Halpert G;Andreoli L;Tincani A;Amital H;Shoenfeld Y
通讯作者：
Shoenfeld Y
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DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Casanova JL
影响因子：
13.3
作者：
Duarte-Garcia, Ali;Pham, Michael M.;Matteson, Eric. L.
通讯作者：
Matteson, Eric. L.
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影响因子：
2.7
作者：
Cheng L;Li H;Li L;Liu C;Yan S;Chen H;Li Y
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Li Y
影响因子：
4.4
作者：
Blitshteyn S;Whitelaw S
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Whitelaw S