Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug.
Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug.
复制标题
DOI：
10.1016/j.pbb.2017.06.015
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Freeman KB
中科院分区：
文献类型：
--
作者：
Perkins FN;Freeman KB
药物成瘾可以被概念化为一种适应不良的决策障碍，其中药物的选择是以牺牲亲社会的非药物替代品为代价的。对药物成瘾决策的研究主要集中在冲动作为成瘾促进者的作用上，特别是药物滥用者倾向于选择小的，立即的收益，而不是较大但延迟的结果（即，延迟折扣）。另一项平行的工作也侧重于吸毒成瘾的决策，重点是确定选择吸毒而不是非吸毒替代品的决定因素（即，药物与非药物选择）。这两条研究轨道都是药物治疗发展的宝贵工具，用于治疗药物成瘾中的适应不良决策，并且在这两种设计中研究了一些常见药物。然而，我们已经观察到，在设计之间的潜在治疗的给药方案中几乎没有一致性，这阻碍了在减少冲动行为和药物选择的单一治疗策略的开发中的一致性。目前的审查提供了一个概述的药物，已在延迟折扣和药物选择的设计进行了测试，并侧重于药物，减少适应不良的选择，在这两种设计。在未来的研究中，提高结果之间的一致性的建议。最后，我们建议使用一种混合的实验方法，使研究人员能够在一个单一的设计中测试治疗方法在减少冲动和药物选择方面的有效性。
Drug addiction can be conceptualized as a disorder of maladaptive decision making in which drugs are chosen at the expense of pro-social, nondrug alternatives. The study of decision making in drug addiction has focused largely on the role of impulsivity as a facilitator of addiction, in particular the tendency for drug abusers to choose small, immediate gains over larger but delayed outcomes (i.e., delay discounting). A parallel line of work, also focused on decision making in drug addiction, has focused on identifying the determinants underlying the choice to take drugs over nondrug alternatives (i.e., drug vs. nondrug choice). Both tracks of research have been valuable tools in the development of pharmacotherapies for treating maladaptive decision making in drug addiction, and a number of common drugs have been studied in both designs. However, we have observed that there is little uniformity in the administration regimens of potential treatments between the designs, which hinders congruence in the development of single treatment strategies to reduce both impulsive behavior and drug choice. The current review provides an overview of the drugs that have been tested in both delay-discounting and drug-choice designs, and focuses on drugs that reduced the maladaptive choice in both designs. Suggestions to enhance congruence between the findings in future studies are provided. Finally, we propose the use of a hybridized, experimental approach that may enable researchers to test the effectiveness of therapeutics at decreasing impulsive and drug choice in a single design.
登录
查看更多内容
影响因子：
13.5
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Koffarnus, Mikhail N.;Gatchalian, Kirstin M.
通讯作者：
Gatchalian, Kirstin M.
影响因子：
--
作者：
Adriani, Walter;Zoratto, Francesca;Laviola, Giovanni
通讯作者：
Laviola, Giovanni
影响因子：
3.4
作者：
Bickel, Warren K.;Landes, Reid D.;Christensen, Darren R.;Jackson, Lisa;Jones, Bryan A.;Kurth-Nelson, Zeb;Redish, A. David
通讯作者：
Redish, A. David
影响因子：
2.3
作者：
Collins, Eric D.;Vosburg, Suzanne K.;Foltin, Richard W.
通讯作者：
Foltin, Richard W.
影响因子：
3.4
作者：
Comer, SD;Walker, EA;Collins, ED
通讯作者：
Collins, ED