Mosquitocidal properties of natural product compounds isolated from Chinese herbs and synthetic analogs of curcumin.
Mosquitocidal properties of natural product compounds isolated from Chinese herbs and synthetic analogs of curcumin.
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DOI：
10.1603/me11117
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发表时间：
2012-03
影响因子：
2.1
通讯作者：
Lan Q
中科院分区：
文献类型：
--
作者：
Anstrom DM;Zhou X;Kalk CN;Song B;Lan Q
由于对当前杀虫剂的抗性以及对环境、健康和监管问题的抗性，天然存在的化合物及其衍生物对于开发针对致病病原体的载体的新杀虫化合物越来越感兴趣。本文报道了58个化合物对埃及伊蚊（Aedesaegypti（L.）以及它们抑制胆固醇与Ae结合的能力。埃及甾醇载体蛋白-2。在测试的化合物中，姜黄素类似物似乎特别有希望，在测试的24种化合物中，有5种是Ae的抑制剂。埃及甾醇载体蛋白-2的EC 50值范围为0.65至62.87 μM，三种姜黄素类似物对四龄埃及伊蚊表现出杀幼虫活性。埃及伊蚊幼虫的LC 50值范围为17.29 - 27.90 μM。增加合成姜黄素类似物的吸引力的是合成大量多样性化合物的相对容易;在本研究中仅对这种多样性的一小部分进行了采样。
Because of resistance to current insecticides and to environmental, health, and regulatory concerns, naturally occurring compounds and their derivatives are of increasing interest for the development of new insecticidal compounds against vectors of disease-causing pathogens. Fifty-eight compounds, either extracted and purified from plants native to China or synthetic analogs of curcumin, were evaluated for both their larvicidal activity against Aedes aegypti (L.) and their ability to inhibit binding of cholesterol to Ae. aegypti sterol carrier protein-2 in vitro. Of the compounds tested, curcumin analogs seem especially promising in that of 24 compounds tested five were inhibitors of Ae. aegyptisterol carrier protein-2 with EC50 values ranging from 0.65 to 62.87 μM, and three curcumin analogs exhibited larvicidal activity against fourth instar Ae. aegypti larvae with LC50 values ranging from 17.29 to 27.90 μM. Adding to the attractiveness of synthetic curcumin analogs is the relative ease of synthesizing a large diversity of compounds; only a small fraction of such diversity has been sampled in this study.
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影响因子：
3.5
作者：
Chen, Zhuo;Liu, Yu-Mei;Zhou, Xia
通讯作者：
Zhou, Xia
影响因子：
2.3
作者：
Adfa, Morina;Yoshimura, Tsuyoshi;Koketsu, Mamoru
通讯作者：
Koketsu, Mamoru
影响因子：
2.4
作者：
Aurade, Ravindra M.;Jayalakshmi, Senigala K.;Sreeramulu, Kuruba
通讯作者：
Sreeramulu, Kuruba
影响因子：
6.5
作者：
Dyer, David H.;Wessely, Vilena;Lan, Que
通讯作者：
Lan, Que
影响因子：
2.6
作者：
Blitzer, EJ;Vyazunova, I;Lan, Q
通讯作者：
Lan, Q