Risk of Transmission and Viral Shedding From the Time of Infection for Respiratory Syncytial Virus in Households.
Risk of Transmission and Viral Shedding From the Time of Infection for Respiratory Syncytial Virus in Households.
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DOI：
10.1093/aje/kwab181
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发表时间：
2021-12-01
影响因子：
5
通讯作者：
Cook AR
中科院分区：
文献类型：
--
作者：
Otomaru H;Sornillo JBT;Kamigaki T;Bado SLP;Okamoto M;Saito-Obata M;Inobaya MT;Segubre-Mercado E;Alday PP;Saito M;Tallo VL;Quiambao BP;Oshitani H;Cook AR
呼吸道合胞病毒（RSV）是全球下呼吸道感染的主要原因，但关于密切接触者之间传播风险随时间变化的报告很少。本研究旨在研究病毒载量轨迹和传播风险之间的关联，以制定更好的疾病传播控制策略。我们在菲律宾比利兰省进行了一项以家庭为基础的前瞻性队列研究，招募了451名参与者，观察急性呼吸道感染的发展。包括在卫生保健机构发现的病例，我们分析了从172名随访参与者中获得的病毒载量数据和症状记录，这些参与者在2018-2019年RSV爆发期间对RSV进行了快速检测。我们开发了一个模型，估计从感染的病毒脱落的时间变化，并评估传输动力学。我们发现，大多数传播事件发生在家庭暴露后约7天内，包括潜在的症状前传播。5岁以下儿童的推断感染风险比5岁以上儿童高3.5倍。这一发现表明，家庭暴露后的最初一周对预防RSV传播特别重要。
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection worldwide, but reports of temporal changes in the risk of transmission among close contacts has been scarce. This study aimed to examine an association between the viral load trajectory and transmission risk to develop a better control strategy for the disease spread. We conducted a household-based prospective cohort study in Biliran Province, the Philippines, and enrolled 451 participants to observe the development of acute respiratory infection. Including the cases found at the health-care facility, we analyzed the data of viral loads with symptom records obtained from 172 followed participants who had household member positive for RSV with a rapid test during an RSV outbreak in 2018–2019. We developed a model estimating a temporal change in the viral shedding from the infection and evaluated transmission dynamics. We found that most transmission events occurred within approximately 7 days of the household exposure, including potential presymptomatic transmissions. The inferred risk of infection among those younger than 5 years was 3.5 times higher than that of those older than 5 years. This finding suggested that the initial week after the household exposure is particularly important for preventing RSV spread.
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新生儿CD8 T细胞层次结构与成年人不同，受呼吸道合胞病毒感染小鼠的内在T细胞特性的影响。
影响因子：
6.7
作者：
Ruckwardt TJ;Malloy AM;Gostick E;Price DA;Dash P;McClaren JL;Thomas PG;Graham BS
通讯作者：
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DOI：
10.1093/infdis/jiy515
发表时间：
2019-01-07
期刊：
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影响因子：
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作者：
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Oshitani H
影响因子：
3.7
作者：
Kosai H;Tamaki R;Saito M;Tohma K;Alday PP;Tan AG;Inobaya MT;Suzuki A;Kamigaki T;Lupisan S;Tallo V;Oshitani H
通讯作者：
Oshitani H
DOI：
10.1016/j.diagmicrobio.2008.08.002
发表时间：
2008-12
影响因子：
2.9
作者：
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通讯作者：
Englund JA
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P