Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus.
Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus.
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DOI：
10.1016/j.diagmicrobio.2008.08.002
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发表时间：
2008-12
影响因子：
2.9
通讯作者：
Englund JA
中科院分区：
文献类型：
--
作者：
Martin ET;Kuypers J;Heugel J;Englund JA
呼吸道合胞病毒（RSV）和人偏肺病毒（hMPV）在儿童呼吸道分泌物中的数量与疾病严重程度之间的关系尚不清楚。我们评估了逆转录酶聚合酶链反应测定的hMPV和RSV病毒载量对疾病特征的影响。资料摘自418例RSV患儿和81例hMPV患儿的病历；在多变量分析中评估相关性，包括连续分析和比较低与高病毒载量。hmpv感染儿童病毒载量的增加与发热、支气管扩张剂使用、胸片检查和住院时间的增加有关。rsv感染儿童病毒载量的增加与住院率、抗生素使用和呼吸率的降低有关。我们的研究描述了在呼吸道疾病评估的大量儿童中，RSV和hMPV的病毒载量与疾病严重程度标志物之间的显著关系。
The relationship between respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) quantity in respiratory secretions and severity of illness in children remains unclear. We assessed the effect of hMPV and RSV viral load as determined by reverse transcriptase polymerase chain reaction on disease characteristics. Data were abstracted from medical records of 418 children with RSV and 81 children with hMPV; associations were evaluated in multivariate analyses, both continuously and comparing lower versus higher viral loads. Increasing viral load in hMPV-infected children was associated with increases in presence of fever, bronchodilator use, obtaining chest radiograph, and length of hospital stay. Increasing viral load in RSV-infected children was associated with decreases in inpatient admissions, use of antibiotics, and respiratory rate. Our study has described a significant relationship between viral load and markers of disease severity for both RSV and hMPV in a large population of children evaluated for respiratory disease.
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影响因子：
6.4
作者：
Klein, MI;Coviello, S;Polack, FP
通讯作者：
Polack, FP
DOI：
10.1016/j.jcv.2004.03.018
发表时间：
2004-10
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Kuypers J;Wright N;Morrow R
通讯作者：
Morrow R
DOI：
10.1016/j.jcv.2004.11.023
发表时间：
2005-08
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Kuypers J;Wright N;Corey L;Morrow R
通讯作者：
Morrow R
影响因子：
5.4
作者：
Woo, PCY;Lau, SKP;Yuen, KY
通讯作者：
Yuen, KY
DOI：
10.1073/pnas.0504666102
发表时间：
2005-09-06
影响因子：
11.1
作者：
Allander, T;Tammi, MT;Andersson, B
通讯作者：
Andersson, B